药物基因组学知识个性化医疗。

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Whirl-Carrillo M, McDonagh EM,赫伯特JM,龚L, Sangkuhl K,刺CF,奥特曼RB,克莱因TE

药物基因组学知识个性化医疗。

中国新药杂志。2012年10月,92 (4):414 - 7。doi: 10.1038 / clpt.2012.96。

PubMed ID

22992668 (在PubMed

]

文摘

药物基因组学知识库(网页)是一种资源,收集、分享,和传播信息的人类遗传变异对药物反应的影响。它提供了临床相关的信息,包括计量指南,带注释的药品标签,和潜在的可操作的gene-drug协会和genotype-phenotype关系。策展人分配水平的证据variant-drug协会使用定义良好的标准基于仔细的文献综述。因此,网页是一个有用的高质量的信息来源支持个性化medicine-implementation项目。

DrugBank数据引用了这篇文章

药物

洛伐他汀

药物反应

反应
异环磷酰胺 DB01181 细胞色素P450 3 a4 细胞色素P450 3 a5 细胞色素P450 2 b6 细胞色素P450 3 a7 3-Dechloroethylifosfamide DBMET00021	细节
奈韦拉平 DB00238 细胞色素P450 2 c9 细胞色素P450 2 d6 细胞色素P450 3 a4 细胞色素P450 3 a5 12-Hydroxynevirapine DBMET00074	细节
奈韦拉平 DB00238 细胞色素P450 3 a4 细胞色素P450 3 a5 2-Hydroxynevirapine DBMET00075	细节
奈韦拉平 DB00238 细胞色素P450 2 d6 细胞色素P450 2 b6 细胞色素P450 3 a4 8-Hydroxynevirapine DBMET00076	细节
奈韦拉平 DB00238 细胞色素P450 2 b6 3-Hydroxynevirapine DBMET00077	细节
氯吡格雷 DB00758 细胞色素P450 3 a4 细胞色素P450 3 a5 细胞色素P450 2 c9 细胞色素P450 2 c19 细胞色素P450 1 a2 细胞色素P450 2 b6 2-Oxoclopidogrel DBMET00098	细节
布洛芬 DB01050 UDP-glucuronosyltransferase 1 - 1 UDP-glucuronosyltransferase 1 - 3 UDP-glucuronosyltransferase 1 - 9 UDP-glucuronosyltransferase 2 b4 UDP-glucuronosyltransferase 2 b7 布洛芬葡糖苷酸 DBMET00153	细节
塞来昔布 DB00482 细胞色素P450 2 c9 细胞色素P450 3 a4 细胞色素P450 2 d6 细胞色素P450 2 c8 Hydroxycelecoxib DBMET00165	细节
氟西汀 DB00472 细胞色素P450 2 d6 细胞色素P450 3 a4 细胞色素P450 2 c9 细胞色素P450 3 a5 细胞色素P450 2 c19 细胞色素P450 1 a2 细胞色素P450 2 b6 Norfluoxetine DBMET00197	细节
咖啡因 DB00201 细胞色素P450 1 a2 细胞色素P450 2 e1 可可碱 DB01412	细节
咖啡因 DB00201 细胞色素P450 1 a2 细胞色素P450 2 e1 细胞色素P450 2 c8 细胞色素P450 2 c9 细胞色素P450 3 a4 茶碱 DB00277	细节
氯丙咪嗪 DB01242 细胞色素P450 1 a2 细胞色素P450 2 c19 细胞色素P450 3 a4 Desmethylclomipramine DBMET00244	细节
丙咪嗪 DB00458 细胞色素P450 1 a2 细胞色素P450 2 c19 细胞色素P450 2 d6 细胞色素P450 3 a4 2-hydroxyimipramine DBMET00254	细节
罗格列酮 DB00412 细胞色素P450 2 c8 细胞色素P450 2 c9 N-Desmethylrosiglitazone DBMET00295	细节
罗格列酮 DB00412 细胞色素P450 2 c8 细胞色素P450 2 c9 para-Hydroxyrosiglitazone DBMET00296	细节
多虑平 DB01142 细胞色素P450 2 d6 细胞色素P450 2 c9 细胞色素P450 2 c19 细胞色素P450 1 a2 细胞色素P450 3 a4 甲醛 DBMET00531 N-desmethyldoxepin DBMET00315	细节
吗啡 DB00295 UDP-glucuronosyltransferase 2 b7 UDP-glucuronosyltransferase 1 - 1 UDP-glucuronosyltransferase 1 - 8 UDP-glucuronosyltransferase 2去往b15 UDP-glucuronosyltransferase 2 b4 UDP-glucuronosyltransferase 1 - 3 吗啡葡糖苷酸 DB06409	细节
吗啡 DB00295 UDP-glucuronosyltransferase 2 b7 UDP-glucuronosyltransferase 1 - 1 morphine-3-glucuronide DBMET00462	细节
罗格列酮 DB00412 细胞色素P450 2 c8 细胞色素P450 2 c9 ortho-Hydroxyrosiglitazone DBMET00470	细节
尼古丁 DB00184 细胞色素P450 2 a6 细胞色素P450 2 b6 尼古丁亚胺 DBMET00516	细节
尼古丁 DB00184 Nornicotine DBMET00520	细节
尼古丁 DB00184 UDP-glucuronosyltransferase 1 - 4 UDP-glucuronosyltransferase 1 - 9 尼古丁葡糖苷酸 DBMET00524	细节
尼古丁 DB00184 二甲基苯胺单氧酶(N-oxide-forming) 3 Nicotine-1”-N-oxide DBMET00533	细节
对乙酰氨基酚 DB00316 UDP-glucuronosyltransferase 1 - 9 UDP-glucuronosyltransferase 1 - 6 UDP-glucuronosyltransferase 1 - 1 UDP-glucuronosyltransferase 2去往b15 UDP-glucuronosyltransferase 1 - 10 对乙酰氨基酚葡糖苷酸 DBMET00580	细节
索拉非尼 DB00398 细胞色素P450 3 a4 吡斯的明 DBMET00624	细节
阿霉素 DB00997 羰基还原酶(NADPH) 1 羰基还原酶(NADPH) 3 Aldo-keto还原酶家族成员1 C3 乙醇脱氢酶(辅酶ii (+)) Doxorubicinol DBMET00647	细节
对乙酰氨基酚 DB00316 Sulfotransferase 1 a1 Sulfotransferase 1 a3/1a4 胆汁盐sulfotransferase 对乙酰氨基酚硫酸盐 DBMET00653	细节
霉酚酸 DB01024 UDP-glucuronosyltransferase 2 b7 霉酚acid-acyl葡糖苷酸 DBMET00662	细节
布洛芬 DB01050 1-hydroxyibuprofen DBMET00668	细节
氯丙咪嗪 DB01242 细胞色素P450 2 d6 2-hydroxyclomipramine DBMET00682	细节
霉酚酸 DB01024 细胞色素P450 2 c8 细胞色素P450 3 a4 细胞色素P450 3 a5 6-O-desmethyl-mycophenolic酸 DBMET00767	细节
氯丙咪嗪 DB01242 细胞色素P450 2 d6 8-hydroxyclomipramine DBMET00777	细节
卡马西平 DB00564 卡马西平2,3-epoxide DBMET00804	细节
多虑平 DB01142 多虑平N-oxide DBMET00844	细节
阿霉素 DB00997 NADH脱氢酶(辅酶q) iron-sulfur蛋白质2,线粒体 NADH脱氢酶(辅酶q) iron-sulfur蛋白质3,线粒体 NADH脱氢酶(辅酶q) iron-sulfur蛋白质7,线粒体 内皮一氧化氮合酶 一氧化氮合酶诱导 一氧化氮合酶,大脑 黄嘌呤脱氢酶和氧化酶 NAD (P) H脱氢酶(醌)1 Doxorubicin-semiquinone DBMET00846	细节
阿霉素 DB00997 NADPH -细胞色素P450还原酶 黄嘌呤脱氢酶和氧化酶 NAD (P) H脱氢酶(醌)1 Doxorubicinol deoxaglycone DBMET00847	细节
依托泊苷 DB00773 UDP-glucuronosyltransferase 1 - 1 依托泊苷葡糖苷酸 DBMET00853	细节
拉米夫定 DB00709 Sulfotransferase 1 a1 拉米夫定亚砜 DBMET00895	细节
拉米夫定 DB00709 Choline-phosphate cytidylyltransferase一 Lamivudine-diphosphate-choline DBMET00896	细节
拉米夫定 DB00709 Lamivudine-diphosphate-ethanolamine DBMET00897	细节
霉酚酸 DB01024 UDP-glucuronosyltransferase 1 - 8 UDP-glucuronosyltransferase 1 - 10 UDP-glucuronosyltransferase 1 - 9 UDP-glucuronosyltransferase 1 - 7 UDP-glucuronosyltransferase 1 - 1 霉酚acid-7-O-glucuronide DBMET00917	细节
罗格列酮 DB00412 N-Despyridinyl罗格列酮 DBMET00942	细节
苯妥英 DB00252 细胞色素P450 2 c9 细胞色素P450 2 c19 苯妥英arene-oxide DBMET00988	细节
索拉非尼 DB00398 UDP-glucuronosyltransferase 1 - 9 索拉非尼beta-D-Glucuronide DBMET01001	细节
NAPQI DBMET00243 谷胱甘肽S-transferase P 谷胱甘肽S-transferaseθ1 谷胱甘肽S-transferaseμ1 对乙酰氨基酚半胱氨酸 DBMET00789	细节
3-Hydroxyibuprofen DBMET00155 细胞色素P450 2 c9 Carboxy-ibuprofen DBMET00808	细节
茶碱 DB00277 细胞色素P450 1 a2 1-Methylxanthine DBMET00271	细节
12-Hydroxynevirapine DBMET00074 12-hydroxynevirapine葡糖苷酸 DBMET00669	细节
8-Hydroxynevirapine DBMET00076 8-hydroxynevirapine葡糖苷酸 DBMET00779	细节
3-Hydroxynevirapine DBMET00077 3-hydroxynevirapine葡糖苷酸 DBMET00712	细节
2-hydroxyimipramine DBMET00254 2-hydroxy-imipramine葡糖苷酸 DBMET00680	细节
3-hydroxycarbamazepine DBMET00710 细胞色素P450 2 c19 细胞色素P450 3 a4 细胞色素P450 3 a5 2,3-Dihydroxycarbamazepine DBMET01101	细节
卡马西平2,3-epoxide DBMET00804 2-hydroxycarbamazepine DBMET00681	细节
尼古丁亚胺 DBMET00516 醛氧化酶 可替宁 DBMET00519	细节
可替宁 DBMET00519 可替宁N-oxide DBMET00529	细节
可替宁 DBMET00519 细胞色素P450 2 a6 3 ' -Hydroxycotinine DBMET00527	细节
可替宁 DBMET00519 Nornicotine DBMET00520	细节
可替宁 DBMET00519 二甲基苯胺单氧酶(N-oxide-forming) 3 Nicotine-1”-N-oxide DBMET00533	细节
可替宁 DBMET00519 UDP-glucuronosyltransferase 1 - 4 UDP-glucuronosyltransferase 1 - 9 可替宁葡糖苷酸 DBMET00517	细节
Hydroxycelecoxib DBMET00165 乙醇脱氢酶1 乙醇脱氢酶1 b Carboxycelecoxib DBMET00810	细节
Carboxycelecoxib DBMET00810 UDP-glucuronosyltransferases (ugt) 塞来昔布葡糖苷酸 DBMET00813	细节
N-desmethyldoxepin DBMET00315 Didesmethyl多虑平 DBMET00834	细节
多虑平N-oxide DBMET00844 多虑平N-oxide葡糖苷酸 DBMET00845	细节
(E) 2-hydroxydoxepin DBMET00873 Hydroxydoxepin葡糖苷酸 DBMET00881	细节
N-desmethyldoxepin DBMET00315 细胞色素P450 2 d6 Hydroxydesmethyl多虑平 DBMET00872	细节
(E) 2-hydroxydoxepin DBMET00873 (E) 2-hydroxy-n-desmethyldoxepin DBMET00874	细节
Hydroxydesmethyl多虑平 DBMET00872 Hydroxydesmethyl多虑平葡糖苷酸 DBMET00879	细节
Desmethylclomipramine DBMET00244 细胞色素P450 1 a2 didesmethylclomipramine DBMET00835	细节
2-hydroxyclomipramine DBMET00682 细胞色素P450 2 d6 2-hydroxydesmethyl氯丙咪嗪 DBMET01069	细节
2-hydroxyclomipramine DBMET00682 2-hydroxyclomipramine葡糖苷酸 DBMET01071	细节
8-hydroxyclomipramine DBMET00777 8-hydroxyclomipramine葡糖苷酸 DBMET01072	细节
8-hydroxyclomipramine DBMET00777 8-hydroxydesmethyl氯丙咪嗪 DBMET01073	细节
2-hydroxydesmethyl氯丙咪嗪 DBMET01069 2-hydroxydesmethyl氯丙咪嗪葡糖苷酸 DBMET01074	细节
8-hydroxydesmethyl氯丙咪嗪 DBMET01073 8-hyroxydesmethyl氯丙咪嗪葡糖苷酸 DBMET01075	细节
阿霉素 DB00997 Doxorubicine hydroxyaglycone DBMET01078	细节
Doxorubicine hydroxyaglycone DBMET01078 Doxirubicinol hydroxyaglycone DBMET01079	细节
Norfluoxetine DBMET00197 UDP-glucuronosyltransferases (ugt) Norfluoxetine葡糖苷酸 DBMET00964	细节
苯妥英arene-oxide DBMET00988 细胞色素P450 1 a2 细胞色素P450 2 a6 细胞色素P450 2 c19 细胞色素P450 2 c8 细胞色素P450 2 c9 细胞色素P450 2 d6 细胞色素P450 2 e1 细胞色素P450 3 a4 环氧化物水解酶1 苯妥英dihydrodiol DBMET00990	细节
苯妥英arene-oxide DBMET00988 Hydroxyphenytoin DBMET00888	细节
Hydroxyphenytoin DBMET00888 细胞色素P450 2 c19 细胞色素P450 3 a5 细胞色素P450 2 c9 细胞色素P450 3 a4 细胞色素P450 3 a7 细胞色素P450 2 b6 细胞色素P450 2 d6 苯妥英苯邻二酚 DBMET00989	细节
Hydroxyphenytoin DBMET00888 UDP-glucuronosyltransferase 1 - 1 UDP-glucuronosyltransferase 1 - 4 UDP-glucuronosyltransferase 1 - 6 UDP-glucuronosyltransferase 1 - 9 Hydroxyphenytoin-O-glucuronide DBMET00889	细节
N-Desmethylrosiglitazone DBMET00295 N-Desmethyl-ortho-hydroxy罗格列酮 DBMET00936	细节
ortho-Hydroxyrosiglitazone DBMET00470 N-Desmethyl-ortho-hydroxy罗格列酮 DBMET00936	细节
N-Desmethylrosiglitazone DBMET00295 N-Desmethyl-para-hydroxy罗格列酮 DBMET00938	细节
para-Hydroxyrosiglitazone DBMET00296 N-Desmethyl-para-hydroxy罗格列酮 DBMET00938	细节
N-Desmethyl-ortho-hydroxy罗格列酮 DBMET00936 N-Desmethyl-ortho-O-sulfate罗格列酮 DBMET00937	细节
ortho-Hydroxyrosiglitazone DBMET00470 ortho-O-Glucuronide罗格列酮 DBMET00968	细节
ortho-Hydroxyrosiglitazone DBMET00470 ortho-O-Sulfate罗格列酮 DBMET00969	细节
N-Desmethylrosiglitazone DBMET00295 N-Desmethyl罗格列酮葡糖苷酸 DBMET01111	细节
para-Hydroxyrosiglitazone DBMET00296 para-O-Glucuronide罗格列酮 DBMET00981	细节
para-Hydroxyrosiglitazone DBMET00296 para-O-Sulfate罗格列酮 DBMET01112	细节
O-Desmethyltramadol DBMET00324 UDP-glucuronosyltransferase 2 b7 UDP-glucuronosyltransferase 1 - 8 O-Desmethyl-tramado葡糖苷酸 DBMET00966	细节
O-Desmethyltramadol DBMET00324 细胞色素P450 2 d6 N, O-didesmethyltramadol DBMET00957	细节
N-Desmethyltramadol DBMET00343 细胞色素P450 2 d6 N, O-didesmethyltramadol DBMET00957	细节
N-Desmethyltramadol DBMET00343 细胞色素P450 3 a4 细胞色素P450 2 b6 N, N-didesmethyltramadol DBMET00954	细节
N, O-didesmethyltramadol DBMET00957 N, N, O-tridesmethyl-tramadol DBMET00956	细节
N, N-didesmethyltramadol DBMET00954 N, N, O-tridesmethyl-tramadol DBMET00956	细节
10日,11-Epoxycarbamazepine DBMET00291 环氧化物水解酶1 10日,11-Dihydroxycarbamazepine DBMET00806	细节
罗格列酮 DB00412 苯氧基乙酸罗格列酮的导数 DBMET01365	细节