Miscellaneous Anxiolytics Sedatives and Hypnotics

Name
Miscellaneous Anxiolytics Sedatives and Hypnotics
Accession Number
DBCAT003678
Description

Not Available

Drugs
Drug Drug Description
Eszopiclone A sedative-hypnotic used in the treatment of insomnia, improving both the latency phase and the maintenance phase of sleep.
Zolpidem A sedative hypnotic used for the short-term treatment of insomnia to improve sleep latency.
Droperidol A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting.
Buspirone An anxiolytic agent used for short-term treatment of generalized anxiety and second-line treatment of depression.
Hydroxyzine An antihistamine used to treat anxiety and tension associated with psychoneuroses, as well as allergic conditions such as pruritus and chronic urticaria.
Dexmedetomidine An alpha-2 agonist used for sedation during various procedures.
Zaleplon A sedative used for short term treatment of insomnia in adults.
Promethazine A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.
Zopiclone A nonbenzodiazepine hypnotic used for the short-term management of insomnia.
Chloral hydrate A mild hypnotic used for experimental purposes that was previously used for the treatment of insomnia.
Valerian A plant used in some non-prescription natural health products.
Suvorexant A orexin receptor antagonist used to treat insomnia that is characterized by difficulties with sleep onset and/or sleep maintenance.
Drugs & Drug Targets
Drug Target Type
Eszopiclone Cytochrome P450 3A4 enzyme
Eszopiclone Gamma-aminobutyric acid receptor subunit alpha-1 target
Eszopiclone Gamma-aminobutyric acid receptor subunit alpha-2 target
Eszopiclone Gamma-aminobutyric acid receptor subunit alpha-3 target
Eszopiclone Gamma-aminobutyric acid receptor subunit alpha-5 target
Eszopiclone Cytochrome P450 2C8 enzyme
Eszopiclone GABA(A) Receptor target
Zolpidem Gamma-aminobutyric acid receptor subunit alpha-1 target
Zolpidem Cytochrome P450 3A4 enzyme
Zolpidem Cytochrome P450 1A2 enzyme
Zolpidem Gamma-aminobutyric acid receptor subunit alpha-2 target
Zolpidem Gamma-aminobutyric acid receptor subunit alpha-3 target
Zolpidem Cytochrome P450 2C9 enzyme
Zolpidem Cytochrome P450 2C19 enzyme
Zolpidem Cytochrome P450 2D6 enzyme
Zolpidem Gamma-aminobutyric acid receptor subunit gamma-2 target
Droperidol Dopamine D2 receptor target
Droperidol Alpha-1A adrenergic receptor target
Buspirone 5-hydroxytryptamine receptor 1A target
Buspirone Dopamine D2 receptor target
Buspirone Cytochrome P450 3A4 enzyme
Buspirone Cytochrome P450 3A5 enzyme
Buspirone Cytochrome P450 3A7 enzyme
Buspirone P-glycoprotein 1 transporter
Buspirone Cytochrome P450 2D6 enzyme
Buspirone Serum albumin carrier
Buspirone Alpha-1-acid glycoprotein 1 carrier
Buspirone Dopamine D3 receptor target
Buspirone Dopamine D4 receptor target
Buspirone Alpha-1 adrenergic receptors target
Hydroxyzine Histamine H1 receptor target
Hydroxyzine Cytochrome P450 2D6 enzyme
Hydroxyzine Cytochrome P450 3A4 enzyme
Hydroxyzine Cytochrome P450 3A5 enzyme
Hydroxyzine Potassium voltage-gated channel subfamily H member 2 target
Hydroxyzine P-glycoprotein 1 transporter
Hydroxyzine Serum albumin carrier
Dexmedetomidine Alpha-2A adrenergic receptor target
Dexmedetomidine Cytochrome P450 2E1 enzyme
Dexmedetomidine Cytochrome P450 1A2 enzyme
Dexmedetomidine Cytochrome P450 1A1 enzyme
Dexmedetomidine Cytochrome P450 2D6 enzyme
Zaleplon Gamma-aminobutyric acid receptor subunit alpha-1 target
Zaleplon Cytochrome P450 3A4 enzyme
Zaleplon Aldehyde oxidase enzyme
Zaleplon Cytochrome P450 3A5 enzyme
Zaleplon Cytochrome P450 3A7 enzyme
Promethazine Dopamine D2 receptor target
Promethazine Histamine H1 receptor target
Promethazine Muscarinic acetylcholine receptor M4 target
Promethazine Muscarinic acetylcholine receptor M1 target
Promethazine Muscarinic acetylcholine receptor M5 target
Promethazine Muscarinic acetylcholine receptor M2 target
Promethazine Muscarinic acetylcholine receptor M3 target
Promethazine Calmodulin target
Promethazine Cytochrome P450 2D6 enzyme
Promethazine Cytochrome P450 2B6 enzyme
Promethazine P-glycoprotein 1 transporter
Promethazine Cytochrome P450 2C9 enzyme
Promethazine Histamine H2 receptor target
Promethazine Alpha adrenergic receptor target
Promethazine P2 Purinoceptors target
Promethazine Voltage-gated sodium channel alpha subunit target
Promethazine Voltage-gated Potassium Channels target
Promethazine Canalicular multispecific organic anion transporter 2 transporter
Promethazine Multidrug resistance-associated protein 4 transporter
Promethazine Serum albumin carrier
Zopiclone Translocator protein target
Zopiclone Cytochrome P450 2C8 enzyme
Zopiclone Cytochrome P450 2C9 enzyme
Zopiclone Cytochrome P450 3A4 enzyme
Zopiclone Prostaglandin G/H synthase 1 enzyme
Zopiclone Gamma-aminobutyric acid receptor subunit alpha-1 target
Zopiclone Gamma-aminobutyric acid receptor subunit alpha-2 target
Zopiclone Gamma-aminobutyric acid receptor subunit alpha-3 target
Zopiclone Gamma-aminobutyric acid receptor subunit alpha-5 target
Suvorexant Orexin receptor type 1 target
Suvorexant Orexin receptor type 2 target
Suvorexant Cytochrome P450 3A4 enzyme
Suvorexant P-glycoprotein 1 transporter