Zinc transporter ZIP3

Details

Name
Zinc transporter ZIP3
Synonyms
  • Solute carrier family 39 member 3
  • ZIP-3
  • ZIP3
  • Zrt- and Irt-like protein 3
Gene Name
SLC39A3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052371|Zinc transporter ZIP3 MVKLLVAKILCMVGVFFFMLLGSLLPVKIIETDFEKAHRSKKILSLCNTFGGGVFLATCF NALLPAVREKLQKVLSLGHISTDYPLAETILLLGFFMTVFLEQLILTFRKEKPSFIDLET FNAGSDVGSDSEYESPFMGGARGHALYVEPHGHGPSLSVQGLSRASPVRLLSLAFALSAH SVFEGLALGLQEEGEKVVSLFVGVAVHETLVAVALGISMARSAMPLRDAAKLAVTVSAMI PLGIGLGLGIESAQGVPGSVASVLLQGLAGGTFLFITFLEILAKELEEKSDRLLKVLFLV LGYTVLAGMVFLKW
Number of residues
314
分子Weight
33600.495
Theoretical pI
Not Available
GO Classification
Functions
zinc ion transmembrane transporter activity
Processes
cell morphogenesis/embryonic cranial skeleton morphogenesis/in utero embryonic development/肢体发展/T cell homeostasis/zinc ion transmembrane transport
Components
integral component of membrane/membrane/plasma membrane
General Function
Acts as a zinc-influx transporter.
Specific Function
Zinc ion transmembrane transporter activity
Pfam Domain Function
Transmembrane Regions
4-24 43-63 86-106 170-190 197-217 230-250 263-283 293-313
Cellular Location
Membrane
Gene sequence
>拼箱| BSEQ0052372 |锌转运体zip2 (SLC39A3)TGGTGAAATTGCTAGTGGCCAAAATCCTGTGCATGGTGGGCGTGTTCTTCTTCATGCTG CTCGGCTCCCTGCTCCCCGTGAAGATCATCGAGACAGATTTTGAGAAGGCCCATCGCTCG AAAAAGATCCTCTCTCTCTGCAACACCTTTGGAGGAGGGGTGTTTCTGGCCACGTGCTTC AACGCTCTGCTGCCCGCTGTGAGGGAAAAGCTCCAGAAGGTCCTGAGCCTCGGCCACATC AGCACCGACTACCCGCTGGCCGAAACCATCCTCCTGCTGGGCTTCTTCATGACCGTCTTC CTGGAGCAGCTGATCCTGACCTTCCGCAAGGAGAAGCCGTCCTTCATCGACCTGGAGACC TTCAACGCCGGATCGGACGTGGGCAGCGACTCGGAGTATGAGAGCCCCTTCATGGGGGGC GCGCGGGGCCACGCGCTGTACGTGGAGCCCCACGGCCACGGCCCCAGCCTGAGCGTGCAG GGCCTCTCGCGCGCCAGCCCCGTGCGCCTGCTCAGCCTGGCCTTCGCGCTGTCGGCCCAC TCGGTCTTTGAGGGCCTGGCCCTGGGCCTGCAGGAGGAGGGGGAGAAAGTGGTGAGCCTG TTCGTGGGGGTGGCCGTCCACGAGACACTGGTGGCCGTGGCCCTGGGCATCAGCATGGCC CGGAGTGCCATGCCCCTGCGGGACGCGGCCAAGCTGGCGGTCACCGTAAGCGCCATGATC CCCCTGGGCATCGGCCTGGGCCTGGGCATTGAGAGCGCCCAGGGCGTGCCGGGCAGCGTG GCGTCCGTGCTGCTGCAGGGCCTGGCGGGCGGCACCTTCCTCTTCATCACCTTCCTGGAG ATCCTGGCCAAGGAGCTGGAGGAGAAGAGTGACCGTCTGCTCAAGGTCCTCTTCCTGGTG CTGGGCTACACCGTCCTGGCCGGGATGGTCTTCCTCAAGTGGTGA
Chromosome Location
19
Locus
19p13.3
External Identifiers
Resource Link
UniProtKB ID Q9BRY0
UniProtKB Entry Name S39A3_HUMAN
HGNC ID HGNC:17128
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  3. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [Article]
  4. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]
  5. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [Article]
  6. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. [Article]
  7. Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S: Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71. doi: 10.1021/pr300630k. Epub 2012 Dec 18. [Article]

Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB14533 Zinc chloride approved, investigational unknown substrate Details
DB14548 Zinc sulfate, unspecified form approved, experimental unknown substrate Details