This drug entry is astuband has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
-
Mebhydrolinis an antihistamine indicated in the treatment of allergies.
- Generic Name
- Mebhydrolin
- DrugBank Accession Number
- DB13808
- Background
-
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
-
Structure for Mebhydrolin (DB13808)
- Weight
-
Average: 276.383
Monoisotopic: 276.162648652 - Chemical Formula
- C19H20N2
- Synonyms
-
- Mebhydrolin
Pharmacology
- Indication
-
Not Available
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- Contraindications & Blackbox Warnings
-
Avoid life-threatening adverse drug eventsImprove clinical decision support with information oncontraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support. - Pharmacodynamics
-
Not Available
- Mechanism of action
- Not Available
- Absorption
-
Not Available
- Volume of distribution
-
Not Available
- Protein binding
-
Not Available
- Metabolism
- Not Available
- Route of elimination
-
Not Available
- Half-life
-
Not Available
- Clearance
-
Not Available
- Adverse Effects
-
Improve decision support & research outcomesWith structured adverse effects data, including:blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data. - Toxicity
-
Not Available
- Pathways
-
Pathway Category Mebhydrolin H1-Antihistamine Action Drug action - Pharmacogenomic Effects/ADRsBrowse all" title="" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug InteractionsLearn More" title="" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
-
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareDroxidopa The therapeutic efficacy of Droxidopa can be increased when used in combination with Mebhydrolin. Ephedrine The therapeutic efficacy of Ephedrine can be increased when used in combination with Mebhydrolin. Epinephrine The therapeutic efficacy of Epinephrine can be increased when used in combination with Mebhydrolin. Levonordefrin The therapeutic efficacy of Levonordefrin can be increased when used in combination with Mebhydrolin. Norepinephrine The therapeutic efficacy of Norepinephrine can be increased when used in combination with Mebhydrolin. Protokylol The therapeutic efficacy of Protokylol can be increased when used in combination with Mebhydrolin. Racepinephrine The therapeutic efficacy of Racepinephrine can be increased when used in combination with Mebhydrolin. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Not Available
Products
-
Drug product information from 10+ global regionsOur datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions. - Product Ingredients
-
Ingredient UNII CAS InChI Key Mebhydrolin napadisylate O5G04RB25M 6153-33-9 CJUOSBUQOWKEKJ-UHFFFAOYSA-N
Categories
- ATC Codes
- R06AX15 — Mebhydrolin
- Drug Categories
- Chemical TaxonomyProvided byClassyfire
-
- Description
- This compound belongs to the class of organic compounds known as n-alkylindoles. These are compounds containing an indole moiety that carries an alkyl chain at the 1-position.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Indoles and derivatives
- Sub Class
- N-alkylindoles
- Direct Parent
- N-alkylindoles
- Alternative Parents
- 3-alkylindoles/Aralkylamines/Substituted pyrroles/Benzene and substituted derivatives/Heteroaromatic compounds/Trialkylamines/Azacyclic compounds/Organopnictogen compounds/Hydrocarbon derivatives
- Substituents
- 3-alkylindole/Amine/Aralkylamine/Aromatic heteropolycyclic compound/Azacycle/Benzenoid/Heteroaromatic compound/Hydrocarbon derivative/Indole/Monocyclic benzene moiety
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 9SUK9B7XVY
- CAS number
- 524-81-2
- InChI Key
- FQQIIPAOSKSOJM-UHFFFAOYSA-N
- InChI
-
InChI = 1 s / C19H20N2 / c1 -20-12-11-19-17(14-20)16-9-5-6-10-18(16)21(19)13-15-7-3-2-4-8-15/h2-10H,11-14H2,1H3
- IUPAC Name
-
5-benzyl-2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole
- SMILES
-
CN1CCC2=C(C1)C1=CC=CC=C1N2CC1=CC=CC=C1
References
- General References
-
- FDA Thailand Product Information: MYDOLIN (mebhydrolin) capsule [Link]
- External Links
-
- Human Metabolome Database
- HMDB0240237
- ChemSpider
- 21129
- 29411
- ChEBI
- 135144
- ChEMBL
- CHEMBL1625607
- ZINC
- ZINC000000001651
- Wikipedia
- Mebhydrolin
Clinical Trials
- Clinical TrialsLearn More" title="" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
-
Phase Status Purpose Conditions Count
Pharmacoeconomics
- Manufacturers
-
Not Available
- Packagers
-
Not Available
- Dosage Forms
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Form Route Strength Tablet, film coated Oral Tablet, coated Tablet Suspension Tablet 50 mg Capsule 50 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
-
Property Value Source Water Solubility 0.0367 mg/mL ALOGPS logP 3.69 ALOGPS logP 3.69 Chemaxon logS -3.9 ALOGPS pKa (Strongest Basic) 7.2 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 8.17 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 88.49 m3·mol-1 Chemaxon Polarizability 32.54 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
-
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created at June 23, 2017 20:49 / Updated at May 21, 2021 10:23