Peroxisome proliferator-activated receptor gamma coactivator 1-beta

Details

Name
Peroxisome proliferator-activated receptor gamma coactivator 1-beta
Synonyms
  • PERC
  • PGC-1-beta
  • PGC-1-related estrogen receptor alpha coactivator
  • PGC1
  • PGC1B
  • PPARGC1
Gene Name
PPARGC1B
Organism
Humans
Amino acid sequence
>拼箱| BSEQ0052207 |过氧物酶体proliferator-activatedreceptor gamma coactivator 1-beta MAGNDCGALLDEELSSFFLNYLADTQGGGSGEEQLYADFPELDLSQLDASDFDSATCFGE LQWCPENSETEPNQYSPDDSELFQIDSENEALLAELTKTLDDIPEDDVGLAAFPALDGGD ALSCTSASPAPSSAPPSPAPEKPSAPAPEVDELSLLQKLLLATSYPTSSSDTQKEGTAWR QAGLRSKSQRPCVKADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPPCLQSP RLPAKEDKEPGEDCPSPQPAPASPRDSLALGRADPGAPVSQEDMQAMVQLIRYMHTYCLP QRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSILRELLAQDVLCDVSKPYR LATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREV RRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSR RLNPELGPWLTFADEPLVPSEPQGALPSLCLAPKAYDVERELGSPTDEDSGQDQQLLRGP QIPALESPCESGCGDMDEDPSCPQLPPRDSPRCLMLALSQSDPTFGKKSFEQTLTVELCG TAGLTPPTTPPYKPTEEDPFKPDIKHSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPE RSELLSHLRHATAQPASQAGQKRPFSCSFGDHDYCQVLRPEGVLQRKVLRSWEPSGVHLE DWPQQGAPWAEAQAPGREEDRSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDL ASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQSP PSKANRQLCSRSRSSSGSSPCHSWSPATRRNFRCESRGPCSDRTPSIRHARKRREKAIGE GRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLTRNRRGEKYGFITYRCSEHAALSLTK GAALRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALPASGKSKYEAMDFDSLLKEAQQ SLH
Number of residues
1023
分子量
113221.09
Theoretical pI
Not Available
GO Classification
Functions
AF-2 domain binding/estrogen receptor binding/nuclear receptor transcription coactivator activity/RNA binding/transcription coregulator activity/transcription factor binding
Processes
actin filament organization/bone trabecula formation/cellular response to reactive oxygen species/intracellular estrogen receptor signaling pathway/mitochondrial transcription/negative regulation of transcription, DNA-templated/ossification/positive regulation of alkaline phosphatase activity/positive regulation of bone resorption/positive regulation of cold-induced thermogenesis/positive regulation of DNA-binding transcription factor activity/positive regulation of osteoclast differentiation/positive regulation of phosphorylation/positive regulation of transcription by RNA polymerase II/regulation of transcription, DNA-templated/response to cAMP/response to glucocorticoid
Components
mediator complex/mitochondrion/nucleoplasm/nucleus
General Function
Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
Specific Function
Af-2 domain binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>拼箱| BSEQ0052208 |过氧物酶体proliferator-activatedreceptor gamma coactivator 1-beta (PPARGC1B) ATGGCGGGGAACGACTGCGGCGCGCTGCTGGACGAAGAGCTCTCCTCCTTCTTCCTCAAC TATCTCGCTGACACGCAGGGTGGAGGGTCCGGGGAGGAGCAACTCTATGCTGACTTTCCA GAACTTGACCTCTCCCAGCTGGATGCCAGCGACTTTGACTCGGCCACCTGCTTTGGGGAG CTGCAGTGGTGCCCAGAGAACTCAGAGACTGAACCCAACCAGTACAGCCCCGATGACTCC GAGCTCTTCCAGATTGACAGTGAGAATGAGGCCCTCCTGGCAGAGCTCACCAAGACCCTG GATGACATCCCTGAAGATGACGTGGGTCTGGCTGCCTTCCCAGCCCTGGATGGTGGAGAC GCTCTATCATGCACCTCAGCTTCGCCTGCCCCCTCATCTGCACCCCCCAGCCCTGCCCCG GAGAAGCCCTCGGCCCCAGCCCCTGAGGTGGACGAGCTCTCACTGCTGCAGAAGCTCCTC CTGGCCACATCCTACCCAACATCAAGCTCTGACACCCAGAAGGAAGGGACCGCCTGGCGC CAGGCAGGCCTCAGATCTAAAAGTCAACGGCCTTGTGTTAAGGCGGACAGCACCCAAGAC AAGAAGGCTCCCATGATGCAGTCTCAGAGCCGAAGTTGTACAGAACTACATAAGCACCTC ACCTCGGCACAGTGCTGCCTGCAGGATCGGGGTCTGCAGCCACCATGCCTCCAGAGTCCC CGGCTCCCTGCCAAGGAGGACAAGGAGCCGGGTGAGGACTGCCCGAGCCCCCAGCCAGCT CCAGCCTCTCCCCGGGACTCCCTAGCTCTGGGCAGGGCAGACCCCGGTGCCCCGGTTTCC CAGGAAGACATGCAGGCGATGGTGCAACTCATACGCTACATGCACACCTACTGCCTCCCC CAGAGGAAGCTGCCCCCACAGACCCCTGAGCCACTCCCCAAGGCCTGCAGCAACCCCTCC CAGCAGGTCAGATCCCGGCCCTGGTCCCGGCACCACTCCAAAGCCTCCTGGGCTGAGTTC TCCATTCTGAGGGAACTTCTGGCTCAAGACGTGCTCTGTGATGTCAGCAAACCCTACCGT CTGGCCACGCCTGTTTATGCCTCCCTCACACCTCGGTCAAGGCCCAGGCCCCCCAAAGAC AGTCAGGCCTCCCCTGGTCGCCCGTCCTCGGTGGAGGAGGTAAGGATCGCAGCTTCACCC AAGAGCACCGGGCCCAGACCAAGCCTGCGCCCACTGCGGCTGGAGGTGAAAAGGGAGGTC CGCCGGCCTGCCAGACTGCAGCAGCAGGAGGAGGAAGACGAGGAAGAAGAGGAGGAGGAA GAGGAAGAAGAAAAAGAGGAGGAGGAGGAGTGGGGCAGGAAAAGGCCAGGCCGAGGCCTG CCATGGACGAAGCTGGGGAGGAAGCTGGAGAGCTCTGTGTGCCCCGTGCGGCGTTCTCGG AGACTGAACCCTGAGCTGGGCCCCTGGCTGACATTTGCAGATGAGCCGCTGGTCCCCTCG GAGCCCCAAGGTGCTCTGCCCTCACTGTGCCTGGCTCCCAAGGCCTACGACGTAGAGCGG GAGCTGGGCAGCCCCACGGACGAGGACAGTGGCCAAGACCAGCAGCTCCTACGGGGACCC CAGATCCCTGCCCTGGAGAGCCCCTGTGAGAGTGGGTGTGGGGACATGGATGAGGACCCC AGCTGCCCGCAGCTCCCTCCCAGAGACTCTCCCAGGTGCCTCATGCTGGCCTTGTCACAA AGCGACCCAACTTTTGGCAAGAAGAGCTTTGAGCAGACCTTGACAGTGGAGCTCTGTGGC ACAGCAGGACTCACCCCACCCACCACACCACCGTACAAGCCCACAGAGGAGGATCCCTTC AAACCAGACATCAAGCATAGTCTAGGCAAAGAAATAGCTCTCAGCCTCCCCTCCCCTGAG GGCCTCTCACTCAAGGCCACCCCAGGGGCTGCCCACAAGCTGCCAAAGAAGCACCCAGAG CGAAGTGAGCTCCTGTCCCACCTGCGACATGCCACAGCCCAGCCAGCCTCCCAGGCTGGC CAGAAGCGTCCCTTCTCCTGTTCCTTTGGAGACCATGACTACTGCCAGGTGCTCCGACCA GAAGGCGTCCTGCAAAGGAAGGTGCTGAGGTCCTGGGAGCCGTCTGGGGTTCACCTTGAG GACTGGCCCCAGCAGGGTGCCCCTTGGGCTGAGGCACAGGCCCCTGGCAGGGAGGAAGAC AGAAGCTGTGATGCTGGCGCCCCACCCAAGGACAGCACGCTGCTGAGAGACCATGAGATC CGTGCCAGCCTCACCAAACACTTTGGGCTGCTGGAGACCGCCCTGGAGGAGGAAGACCTG GCCTCCTGCAAGAGCCCTGAGTATGACACTGTCTTTGAAGACAGCAGCAGCAGCAGCGGC GAGAGCAGCTTCCTCCCAGAGGAGGAAGAGGAAGAAGGGGAGGAGGAGGAGGAGGACGAT GAAGAAGAGGACTCAGGGGTCAGCCCCACTTGCTCTGACCACTGCCCCTACCAGAGCCCA CCAAGCAAGGCCAACCGGCAGCTCTGTTCCCGCAGCCGCTCAAGCTCTGGCTCTTCACCC TGCCACTCCTGGTCACCAGCCACTCGAAGGAACTTCAGATGTGAGAGCAGAGGGCCGTGT TCAGACAGAACGCCAAGCATCCGGCACGCCAGGAAGCGGCGGGAAAAGGCCATTGGGGAA GGCCGCGTGGTGTACATTCAAAATCTCTCCAGCGACATGAGCTCCCGAGAGCTGAAGAGG CGCTTTGAAGTGTTTGGTGAGATTGAGGAGTGCGAGGTGCTGACAAGAAATAGGAGAGGC GAGAAGTACGGCTTCATCACCTACCGGTGTTCTGAGCACGCGGCCCTCTCTTTGACAAAG GGCGCTGCCCTGAGGAAGCGCAACGAGCCCTCCTTCCAGCTGAGCTACGGAGGGCTCCGG CACTTCTGCTGGCCCAGATACACTGACTACGATTCCAATTCAGAAGAGGCCCTTCCTGCG TCAGGGAAAAGCAAGTATGAAGCCATGGATTTTGACAGCTTACTGAAAGAGGCCCAGCAG AGCCTGCATTGA
Chromosome Location
5
Locus
5q32
External Identifiers
Resource Link
UniProtKB ID Q86YN6
UniProtKB Entry Name PRGC2_HUMAN
HGNC ID HGNC:30022
一般引用
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  5. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
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Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB01118 Amiodarone approved, investigational unknown agonist Details