Potassium voltage-gated channel subfamily V member 1

Details

Name
Potassium voltage-gated channel subfamily V member 1
Synonyms
  • Neuronal potassium channel alpha subunit HNKA
  • Voltage-gated potassium channel subunit Kv8.1
Gene Name
KCNV1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052269|Potassium voltage-gated channel subfamily V member 1 MPSSGRALLDSPLDSGSLTSLDSSVFCSEGEGEPLALGDCFTVNVGGSRFVLSQQALSCF PHTRLGKLAVVVASYRRPGALAAVPSPLELCDDANPVDNEYFFDRSSQAFRYVLHYYRTG RLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDFKKDTEDQESQHES EQDFSQGPCPTVRQKLWNILEKPGSSTAARIFGVISIIFVVVSIINMALMSAELSWLDLQ LLEILEYVCISWFTGEFVLRFLCVRDRCRFLRKVPNIIDLLAILPFYITLLVESLSGSQT TQELENVGRIVQVLRLLRALRMLKLGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIF STVEYFAEQSIPDTTFTSVPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVL ALPIAIINDRFSACYFTLKLKEAAVRQREALKKLTKNIATDSYISVNLRDVYARSIMEML RLKGRERASTRSSGGDDFWF
Number of residues
500
分子量
56303.305
Theoretical pI
Not Available
GO Classification
Functions
ion channel inhibitor activity/potassium channel regulator activity/voltage-gated potassium channel activity
Processes
potassium ion transmembrane transport/potassium ion transport/protein homooligomerization/regulation of ion transmembrane transport
Components
integral component of membrane/integral component of plasma membrane/plasma membrane/voltage-gated potassium channel complex
General Function
Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.
Specific Function
Ion channel inhibitor activity
Pfam Domain Function
Transmembrane Regions
211-231 239-259 277-297 310-331 346-366 407-427
Cellular Location
细胞会员ane
Gene sequence
>lcl|BSEQ0052270|Potassium voltage-gated channel subfamily V member 1 (KCNV1) ATGCCTTCCAGCGGCAGAGCGCTGCTGGACTCGCCGCTGGACAGCGGCTCCCTGACCTCC CTGGACTCTAGTGTCTTCTGCAGCGAGGGTGAAGGGGAGCCCTTGGCGCTCGGGGACTGC TTCACGGTCAACGTGGGCGGCAGCCGCTTCGTGCTCTCGCAGCAGGCGCTGTCCTGCTTC CCGCACACGCGCCTTGGCAAGCTGGCCGTGGTGGTGGCTTCCTACCGCCGCCCCGGGGCC CTGGCCGCCGTGCCCAGCCCTCTGGAGCTTTGCGACGATGCCAACCCCGTGGACAACGAG TACTTCTTCGACCGCAGCTCGCAGGCGTTCCGATATGTCCTGCACTACTACCGCACCGGC CGCCTGCATGTCATGGAGCAGCTGTGCGCGCTCTCCTTCCTGCAGGAGATCCAGTACTGG GGCATCGATGAGCTCAGCATCGATTCCTGCTGCAGGGACAGATACTTCAGAAGGAAAGAG CTGAGTGAAACTTTAGACTTCAAGAAGGACACAGAAGACCAGGAAAGTCAACATGAGAGT GAACAGGACTTCTCCCAAGGACCTTGTCCCACTGTTCGCCAGAAGCTCTGGAATATCCTG GAGAAACCTGGATCTTCCACAGCTGCCCGTATCTTTGGCGTCATCTCCATTATCTTCGTG GTGGTGTCCATCATTAACATGGCCCTGATGTCAGCTGAGTTAAGCTGGCTGGACCTGCAG CTGCTGGAAATCCTGGAGTATGTGTGCATTAGCTGGTTCACCGGGGAGTTTGTCCTCCGC TTCCTGTGTGTGCGGGACAGGTGTCGCTTCCTAAGAAAGGTGCCAAACATCATAGACCTC CTTGCCATCTTGCCCTTCTACATCACTCTTCTGGTAGAGAGCCTAAGTGGGAGCCAGACC ACGCAGGAGCTGGAGAACGTGGGGCGCATTGTCCAGGTGTTGAGGCTGCTCAGGGCTCTG CGCATGCTAAAGCTGGGCAGACATTCCACAGGATTACGCTCCCTTGGGATGACAATCACC CAGTGTTACGAAGAAGTCGGCCTACTGCTCCTATTTCTATCCGTGGGAATCTCTATATTT TCAACTGTAGAATACTTTGCTGAGCAAAGCATTCCTGACACAACCTTCACAAGTGTCCCT TGTGCATGGTGGTGGGCCACCACCTCTATGACTACTGTGGGATATGGGGACATTAGACCA GACACCACCACAGGCAAAATCGTGGCCTTCATGTGTATATTATCGGGAATTCTTGTCTTG GCCTTGCCTATTGCTATTATTAACGATCGCTTCTCTGCTTGCTACTTCACCTTGAAACTC AAGGAAGCAGCTGTTAGACAGCGTGAAGCCCTAAAGAAGCTTACCAAGAATATAGCCACT GACTCATATATCAGTGTTAACTTGAGAGATGTCTATGCCCGGAGTATCATGGAGATGCTG CGACTGAAAGGCAGAGAAAGAGCAAGTACTAGGAGCAGCGGGGGAGATGATTTCTGGTTT TGA
Chromosome Location
8
Locus
8q23.2
External Identifiers
Resource Link
UniProtKB ID Q6PIU1
UniProtKB Entry Name KCNV1_HUMAN
HGNC ID HGNC:18861
General References
  1. Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C, Mattei MG, Lazdunski M: Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels. EMBO J. 1996 Jul 1;15(13):3322-31. [Article]
  2. 佐野,三米,中村M,上野年代,田边H, Kaneko S: Positional candidate approach for the gene responsible for benign adult familial myoclonic epilepsy. Epilepsia. 2002;43 Suppl 9:26-31. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  4. Salinas M, de Weille J, Guillemare E, Lazdunski M, Hugnot JP: Modes of regulation of shab K+ channel activity by the Kv8.1 subunit. J Biol Chem. 1997 Mar 28;272(13):8774-80. [Article]

Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB00228 Enflurane approved, investigational, vet_approved unknown inhibitoractivator Details
DB01069 Promethazine approved, investigational unknown inducer Details
DB01110 Miconazole approved, investigational, vet_approved unknown inhibitor Details