Isocitrate dehydrogenase [NADP] cytoplasmic

Details

Name
Isocitrate dehydrogenase [NADP] cytoplasmic
Synonyms
  • 1.1.1.42
  • Cytosolic NADP-isocitrate dehydrogenase
  • IDH
  • IDP
  • NADP(+)-specific ICDH
  • Oxalosuccinate decarboxylase
  • PICD
Gene Name
IDH1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0019087|Isocitrate dehydrogenase [NADP] cytoplasmic MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
Number of residues
414
分子量
46659.005
Theoretical pI
7.0
GO Classification
Functions
isocitrate dehydrogenase (NADP+) activity/magnesium ion binding/NAD binding/NADP binding/protein homodimerization activity/receptor binding
Processes
2-oxoglutarate metabolic process/cellular lipid metabolic process/female gonad development/glutathione metabolic process/glyoxylate cycle/isocitrate metabolic process/NADPH regeneration/regulation of phospholipid biosynthetic process/regulation of phospholipid catabolic process/response to oxidative stress/response to steroid hormone/small molecule metabolic process/tricarboxylic acid cycle
Components
cytoplasm/cytosol/extracellular exosome/mitochondrion/peroxisomal matrix/peroxisome
General Function
受体结合
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0019088|Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) ATGTCCAAAAAAATCAGTGGCGGTTCTGTGGTAGAGATGCAAGGAGATGAAATGACACGA ATCATTTGGGAATTGATTAAAGAGAAACTCATTTTTCCCTACGTGGAATTGGATCTACAT AGCTATGATTTAGGCATAGAGAATCGTGATGCCACCAACGACCAAGTCACCAAGGATGCT GCAGAAGCTATAAAGAAGCATAATGTTGGCGTCAAATGTGCCACTATCACTCCTGATGAG AAGAGGGTTGAGGAGTTCAAGTTGAAACAAATGTGGAAATCACCAAATGGCACCATACGA AATATTCTGGGTGGCACGGTCTTCAGAGAAGCCATTATCTGCAAAAATATCCCCCGGCTT GTGAGTGGATGGGTAAAACCTATCATCATAGGTCGTCATGCTTATGGGGATCAATACAGA GCAACTGATTTTGTTGTTCCTGGGCCTGGAAAAGTAGAGATAACCTACACACCAAGTGAC GGAACCCAAAAGGTGACATACCTGGTACATAACTTTGAAGAAGGTGGTGGTGTTGCCATG GGGATGTATAATCAAGATAAGTCAATTGAAGATTTTGCACACAGTTCCTTCCAAATGGCT CTGTCTAAGGGTTGGCCTTTGTATCTGAGCACCAAAAACACTATTCTGAAGAAATATGAT GGGCGTTTTAAAGACATCTTTCAGGAGATATATGACAAGCAGTACAAGTCCCAGTTTGAA GCTCAAAAGATCTGGTATGAGCATAGGCTCATCGACGACATGGTGGCCCAAGCTATGAAA TCAGAGGGAGGCTTCATCTGGGCCTGTAAAAACTATGATGGTGACGTGCAGTCGGACTCT GTGGCCCAAGGGTATGGCTCTCTCGGCATGATGACCAGCGTGCTGGTTTGTCCAGATGGC AAGACAGTAGAAGCAGAGGCTGCCCACGGGACTGTAACCCGTCACTACCGCATGTACCAG AAAGGACAGGAGACGTCCACCAATCCCATTGCTTCCATTTTTGCCTGGACCAGAGGGTTA GCCCACAGAGCAAAGCTTGATAACAATAAAGAGCTTGCCTTCTTTGCAAATGCTTTGGAA GAAGTCTCTATTGAGACAATTGAGGCTGGCTTCATGACCAAGGACTTGGCTGCTTGCATT AAAGGTTTACCCAATGTGCAACGTTCTGACTACTTGAATACATTTGAGTTCATGGATAAA CTTGGAGAAAACTTGAAGATCAAACTAGCTCAGGCCAAACTTTAA
Chromosome Location
2
Locus
2q33.3
External Identifiers
Resource Link
UniProtKB ID O75874
UniProtKB Entry Name IDHC_HUMAN
GenBank Protein ID 3641398
GenBank Gene ID AF020038
GenAtlas ID IDH1
HGNC ID HGNC:5382
一般References
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Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB01727 Isocitric Acid experimental unknown Details
DB03461 Nicotinamide adenine dinucleotide phosphate experimental unknown Details
DB09374 Indocyanine green acid form approved, investigational no cofactor Details
DB14568 Ivosidenib approved, investigational yes inhibitor Details