体外抗菌活性cefpiramide和其他广谱抗生素在中国对440年临床分离株。
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王H,于Y,谢X,王C,张Y, Y元,张X,刘J,陈王P M
体外抗菌活性cefpiramide和其他广谱抗生素在中国对440年临床分离株。
J感染Chemother。2000年6月,6 (2):81 - 5。
- PubMed ID
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11810540 (在PubMed]
- 文摘
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cefpiramide的体外抗菌活性相比其他15个广谱头孢菌素。共有440名临床株细菌,其中包括9细菌物种,在1998年被孤立的从我们的医院。cefpiramide的最小抑制浓度(麦克风)和五个其他抗生素被确定为每一个物种,采用琼脂稀释法。麦克风cefpiramide大肠杆菌和肺炎克雷伯菌是高于其他三个第三代头孢菌素,(如头孢哌酮、头孢他啶和头孢曲松钠)。百分之五十一(26/51)的肠杆菌抵抗cefpiramide泄殖腔隔离。头孢哌酮/ sulbactam和头孢吡肟对大肠下水道有更大的活动(电阻,分别3.9%和19.6%)高于cefpiramide。Cefpiramide是更积极的对铜绿假单胞菌(电阻率、12%)比头孢哌酮、头孢他啶、头孢曲松、aztreonam,头孢吡肟。Cefpiramide-resistant铜绿假单胞菌菌株对头孢他啶,但27%的ceftazidime-resistant菌株容易cefpiramide;15.3%的cefpiramide-resistant s maltophilia菌株也容易头孢他啶,但50%的ceftazidime-resistant菌株仍容易受到cefpiramide。头孢哌酮/ sulbactam是最活性剂对鲍曼不动杆菌,显示电阻率为2%。 Ampicillin/sulbactam, ceftazidime, and cefpiramide were the second most active agents, and about 50% of the tested strains were susceptible to these three antibiotics. Cefpiramide had an activity comparable to that of all tested beta-lactams against oxacillin-susceptible Staphylococcus aureus (MIC90, 2 microg/ml). Against Streptococcus pneumoniae and Haemophilus influenzae, cefpiramide had good activity, with an MIC90 concentration at which 90% of the strain was inhibited of 1 microg/ml and 0.5 microg/ml, respectively. These results indicated that cefpiramide was more active against glucose non-fermenting bacteria than against Enterobacteriaceae, and was very active against oxacillin-susceptible Staphylo-coccus aureus, S. pneumoniae, and H. influenzae. Thus, cefpiramide may be a good choice of drug for the treatment of patients with infections with glucose non-fermenting bacteria and community acquired infections.
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