绝经后低骨密度妇女静脉注射唑来膦酸。
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Reid IR, Brown JP, Burckhardt P, Horowitz Z, Richardson P, Trechsel U, Widmer A, Devogelaer JP, Kaufman JM, Jaeger P, Body JJ, Brandi ML, Broell J, Di Micco R, Genazzani AR, Felsenberg D, Happ J, Hooper MJ, Ittner J, Leb G, Mallmin H, Murray T, Ortolani S, Rubinacci A, Saaf M, Samsioe G, Verbruggen L, Meunier PJ
绝经后低骨密度妇女静脉注射唑来膦酸。
中华外科杂志2002,28(9):653-61。
- PubMed ID
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11870242 (PubMed视图］
- 摘要
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背景:双磷酸盐是治疗骨质疏松症的有效药物。它们的低生物利用度和低效力需要经常空腹给药，这可能会降低依从性。胃肠道不耐受限制最大剂量。虽然已经使用了间歇性静脉注射治疗，但尚未系统地探索最佳剂量和给药间隔。方法:我们在一项为期一年的随机、双盲、安慰剂对照试验中，研究了五种唑来膦酸(最有效的双膦酸盐)方案对351名骨密度低的绝经后妇女骨转换和骨密度的影响。女性接受安慰剂或唑来膦酸静脉注射，剂量分别为0.25 mg、0.5 mg或1mg，间隔3个月。此外，一组接受每年4毫克的单次剂量，另一组接受两次2毫克的剂量，间隔6个月。腰椎骨密度是主要终点。结果:所有唑来膦酸组的骨密度都有相似的增加，脊柱的骨密度比安慰剂组高4.3 - 5.1% (P<0.001)，股骨颈的骨密度比安慰剂组高3.1 - 3.5% (P<0.001)。在整个研究过程中，所有唑来膦酸组的骨吸收生化指标均被显著抑制。 Myalgia and pyrexia occurred more commonly in the zoledronic acid groups, but treatment-related dropout rates were similar to that in the placebo group. CONCLUSIONS: Zoledronic acid infusions given at intervals of up to one year produce effects on bone turnover and bone density as great as those achieved with daily oral dosing with bisphosphonates with proven efficacy against fractures, suggesting that an annual infusion of zoledronic acid might be an effective treatment for postmenopausal osteoporosis.
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