静脉注射alfentanil和氯胺酮的浓度效应关系周围感觉神经的阈值,触诱发痛和痛觉过敏的神经性疼痛。

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梁,华莱士女士,山脊路B, Yaksh T

静脉注射alfentanil和氯胺酮的浓度效应关系周围感觉神经的阈值,触诱发痛和痛觉过敏的神经性疼痛。

痛苦。2001年3月,91 (2):177 - 87。

PubMed ID

11240090 (在PubMed

]

文摘

μ阿片受体激动剂和n -甲基- d -门冬氨酸)受体拮抗剂与神经性疼痛的规定在post-nerve损伤临床疼痛模型。本研究特征的影响通过静脉注入alfentanil (mu-receptor受体激动剂)和氯胺酮(一种门冬氨酸受体拮抗剂)对人体神经性疼痛,特点是触诱发痛和痛觉过敏。使用苯海拉明作为安慰剂,alfentanil在随机双盲和氯胺酮注入时尚1周除了通过计算机控制输液泵(CCI)设定的目标是等离子体水平的alfentanil在25日,50和75 ng / ml和氯胺酮在50岁,100和150 ng / ml。初每个输液和每个目标血浆水平,基本生命体征,感觉神经的测试,包括热阈值、热疼痛和冯·弗雷灯丝阈值和自发和诱发疼痛分数。此外,领域的异常性疼痛或痛觉过敏抚摸和5.18·冯·弗雷灯丝被映射在每个输液的开始和结束。总共七个男人和五个女人post-nerve伤害触诱发痛和痛觉过敏都参加这项研究。海拔寒冷、温暖、热疼痛和冯·弗雷触觉阈值被发现。剂量依赖性增加冷和疼痛阈值,减少抚摸疼痛分数表示alfentanil和氯胺酮注入。此外,alfentanil显示统计上显著的剂量依赖性降低自发和冯·弗雷疼痛分数。alfentanil和氯胺酮注入显示减少抚摸痛觉过敏的面积和氯胺酮显著减少·冯·弗雷痛觉过敏。 No significant CNS side effects and changes in vital signs were noted. A partial deafferentation state was found in the post-nerve injury patients who presented with allodynia and hyperalgesia. The effects of alfentanil on cold and cold pain thresholds and spontaneous pain scores correlates with previous studies suggesting an opiate central analgesic effect. In addition, the reduction of the hyperalgesic area and evoked pain scores with the alfentanil infusion suggests that opioids may have some peripheral effects in the post-nerve injury patients. Therefore, clinical utilization of opioids with careful titration may be beneficial in post-nerve injury patients with partial deafferentation. With the absence of significant CNS side effects, the ketamine infusion not only demonstrated the well-documented spinal cord mechanism of the NMDA receptor, but the result of the current study also suggests that a peripheral mechanism of NMDA receptor may exist. The relationship between central sensitization and regulation of peripheral NMDA-receptor expression requires further investigation.

DrugBank数据引用了这篇文章

药物靶点

药物	目标	类	生物	药理作用	行动
Alfentanil	Mu-type阿片受体	蛋白质	人类	是的	受体激动剂	细节