茶碱与grepafloxacin和华法林相互作用研究。

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Efthymiopoulos C,布拉姆SL, Maroli,布卢姆B

茶碱与grepafloxacin和华法林相互作用研究。

Pharmacokinet。1997; 33增刊1:39-46。

PubMed ID

9433655 (在PubMed

]

文摘

两个第一阶段试验,包括16名健康成人志愿者进行调查grepafloxacin之间可能的相互作用和茶碱或华法林。在茶碱的研究中,grepafloxacin 600毫克每天按时接种一次10天至12志愿者接受维持剂量茶碱。这剂量茶碱旨在生产意味着血清茶碱浓度为7.5 mg / L;4志愿者收到茶碱+安慰剂。茶碱的药代动力学参数测定grepafloxacin grepafloxacin治疗和10天之前或安慰剂。茶碱浓度和峰值曲线下的面积显著增加grepafloxacin治疗期间,和明显总间隙茶碱降低了大约50%。没有观察到变化在安慰剂组和茶碱似乎没有影响grepafloxacin的药物动力学。华法令阻凝剂研究,grepafloxacin 600毫克每天一次14天的志愿者接受华法林维持剂量。华法林是停止在过去4天grepafloxacin管理。华法令阻凝剂的药效学grepafloxacin管理后并没有改变。 Similarly, warfarin had no significant effect on the pharmacokinetics of grepafloxacin. We conclude that during treatment with grepafloxacin maintenance, doses of theophylline should be reduced by 50%, and we recommend that serum concentrations of theophylline be monitored during treatment with grepafloxacin. However, no dose adjustment is necessary for grepafloxacin when it is coadministered with theophylline, and dose adjustment does not seem to be required in concomitant treatment with grepafloxacin and warfarin.

DrugBank数据引用了这篇文章

药物酶

药物	酶	类	生物	药理作用	行动
Grepafloxacin	细胞色素P450 1 a2	蛋白质	人类	未知的	底物 抑制剂	细节