光动力治疗与motexafin镏直肠癌:临床前模型的狗。

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罗斯嗯,Smelstoys是的,戴维斯GJ, Kapatkin,皮耶罗F, Reineke E,王H,朱镕基TC,布施TM, Yodh AG,哈恩SM

光动力治疗与motexafin镏直肠癌:临床前模型的狗。

医学杂志》2006年10月,135 (2):323 - 30。2006年5月2日Epub。

PubMed ID

16650871 (在PubMed

]

文摘

目的:直肠癌局部复发仍然是一个重要的临床问题,尽管多模治疗。光动力疗法(PDT)是一个生成肿瘤癌症治疗杀死通过单线态氧的产生细胞含有photosensitizing药物暴露在特定波长的激光。PDT是一种很有前途的方法预防直肠癌局部复发的原因有几个:肿瘤细胞可能有选择地保留光敏剂含量高于正常组织,骨盆mesorectal切除后是一个固定的空间适合术中照明,和PDT可以生成毒性组织厚达1厘米。本研究评估安全、组织穿透730纳米的光,正常组织毒性和手术结果的狗模型直肠切除后motexafin lutetium-mediated光动力治疗。方法:10混合品种的狗。八只狗接受直肠切除术和低直肠端到端钉吻合。六只狗收到photosensitizing代理motexafin镏(MLu Pharmacyclics, Inc ., CA) 2毫克/公斤术前接受后续盆腔照明730海里的远端直肠以及光与光剂量范围从0.5 J /厘米(2)10 J /厘米(2)药后三个小时。两只狗收到灯,但没有药物,接受直肠切除术和low-rectal钉吻合。两只狗进行中线剖腹手术和骨盆的照明。光穿透小肠组织决心,直肠,盆腔侧壁,和皮肤。 Clinical outcomes were recorded. Animals were sacrificed at 14 days and histological evaluation was performed. RESULTS: All dogs recovered uneventfully. No dog suffered an anastomotic leak. Severe tissue toxicity was not seen. Histological findings at necropsy revealed mild enteritis in all dogs. The excitation light penetration depths were 0.46 +/- 0.18, 0.46 +/- 0.15, and 0.69 +/- 0.39 cm, respectively, for rectum, small bowel, and peritoneum in dogs that had received MLu. For control dogs without photosensitizer MLu, the optical penetration depths were longer: 0.92 +/- 0.63, 0.67 +/- 0.10, and 1.1 +/- 0.80 cm for rectum, small bowel, and peritoneum, respectively. CONCLUSION: Low rectal stapled anastomosis is safe when performed with MLu-mediated pelvic PDT in a dog model. Significant tissue penetration of 730 nm light into the rectum and pelvic sidewall was revealed without generation of significant toxicity or histological sequelae. Penetration depths of 730 nm light in pelvic tissue suggest that microscopic residual disease of less than 5 mm are likely to be treated adequately with MLu-mediated PDT. This approach merits further investigation as an adjuvant to total mesorectal excision and chemoradiation for rectal cancer.

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药物

Motexafin镏