睾酮的药代学和药效学enanthate和二氢睾酮enanthate在非人类的灵长类动物。
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Weinbauer GF, Jackwerth B, Yoon码,Behre嗯,杨CH, Nieschlag E
睾酮的药代学和药效学enanthate和二氢睾酮enanthate在非人类的灵长类动物。
Acta性(Copenh)。1990年4月,122 (4):432 - 42。
- PubMed ID
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2333732 (在PubMed]
- 文摘
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睾酮的药代学和药效学enanthate和dihydrotestosterone-enanthate orchidectomized在猕猴身上比较(猕猴属fascicularis)和完整的促agonist-suppressed恒河猴(解剖)。后一个im注射32.8毫克睾酮enanthate dihydrotestosterone-enanthate或32.7毫克,例如23.6毫克纯类固醇,orchidectomized猕猴,血清睾酮和双氢睾酮水平升至400和800%的基线,分别在24 h。雄激素水平保持在这个范围3 - 5天之后连续下降,直到基线值是4 - 5周后获得。下的地区睾酮和dihydrotestosterone-curves 2290 + / - 340之间没有显著性差异(dihydrotestosterone-enanthate) vs 2920 + / - 485 (testosterone-enanthate)表明类似的类固醇被释放相应的酯制备。的意思是终端消除阶段的半衰期估计4和7天testosterone-enanthate和dihydrotestosterone-enanthate分别。在第二个实验恒河猴,在四周的时间间隔,sc植入可降解的聚丙醇:聚乳酸纤维polyglycolide杆加载与促性腺buserelin。最后注射在20周。促性腺激素抑制治疗血清生物活性LH、睾酮和双氢睾酮的水平,睾丸大小、精子生产,开创性的肉碱含量。射精对电刺激的反应和手淫的行为被废除。睾酮或二氢睾酮注射剂量一样有在10周以上,14日,17岁和20促性腺激素治疗。血清睾酮和双氢睾酮水平刺激9 - 4倍,分别。 Mean half-life estimates for testosterone-enanthate and dihydrotestosterone were 5 and 7 days, respectively. Both ester preparations completely restored the ejaculatory response, ejaculate size, masturbatory behaviour, and seminal carnitine levels. In conclusion, androgen substitution with dihydrotestosterone-enanthate, in equivalent doses, is as effective as testosterone-enanthate in restoring reproductive functions in hypogonadal monkeys.
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- 药物