高压氧增强5-氨基水杨酸治疗大鼠醋酸性结肠炎的疗效。
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Gorgulu S, Yagci G, Kaymakcioglu N, Ozkara M, Kurt B, Ozcan A, Kaya O, Sadir S, Tufan T
高压氧增强5-氨基水杨酸治疗大鼠醋酸性结肠炎的疗效。
地质科学，2006,3,51(3):480-7。
- PubMed ID
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16614956 (PubMed视图］
- 摘要
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本研究的目的是评估高压氧单独和联合5-氨基水杨酸对乙酸诱导的结肠炎模型的有效性，乙酸诱导的结肠炎模型是一种著名的大鼠炎症性肠病实验模型。大鼠随机分为五组。非结肠炎对照组大鼠灌胃等渗生理盐水，其余各组大鼠结肠灌胃4%醋酸。2组为对照组，不加治疗。3组，4组，5组高压氧，5-氨基水杨酸。分别采用5-氨基水杨酸+高压氧治疗。给药醋酸引起所有动物的炎症反应。2组病理评分明显高于其他各组。5-氨基水杨酸和高压氧显著降低了组织病理学评分(P < 0.05)。5-氨基水杨酸也显著降低了髓过氧化物酶的活性(P < 0.05)，而高压氧没有降低髓过氧化物酶活性。 The most prominent ameliorative effect, however, was seen in group 5 and the histopathologic score and myeloperoxidase activity were significantly lower than in groups 3 (P < 0.05) and 4 (P < 0.001). Hydroxyproline level also increased significantly in group 5, but not in groups 3 and 4 (P < 0.001). These findings indicate that hyperbaric oxygen therapy is effective in reducing the extent of colitis induced by acetic acid, although it is not as potent as 5-aminosalicylic acid. The combination of hyperbaric oxygen and 5-aminosalicylic acid, however, led to a much more prominent reduction in the severity of colitis. Hyperbaric oxygen may have a promising place in the treatment of inflammatory bowel disease.