激活骨关节炎患者比较Lornoxicam和万络(颜色)学习。

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激活骨关节炎患者比较Lornoxicam和万络(颜色)学习。

中国药物Investig。2004; 24 (4): 227 - 36。

PubMed ID

17516707 (在PubMed

]

文摘

背景和目的:活动能力受损和痛苦意味着失去与风湿性疾病患者的生活质量。因此治疗的最初目的是快速和高效的镇痛以达到最好的结果对这些病人。Lornoxicam强大的镇痛和抗炎非甾体抗炎药与平衡cyclo-oxygenase (COX) 1 /抑制COX - 2和良好的耐受性。过程中选择性cox - 2抑制剂的开发,维护,cox - 2抑制剂降低受伤的风险上胃肠道(GI)束类似功效的经典的非甾体抗炎药。然而,临床试验比较两种物质从未执行。在目前的研究中我们调查的治疗骨关节炎患者lornoxicam相比,与万络的选择性cox - 2抑制剂治疗。这个多中心临床研究集中在疗效和耐受性。患者和方法:共有2520名患者(其中大部分是与骨关节炎治疗平均在25天。治疗前后患者记录他们的个人成绩有关运动的疼痛,在休息和晚上,和个人的晨僵时间以及随之而来的等级限制。在研究结束的所有个人判断治疗的疗效和安全性。 RESULTS: All improvements in each efficacy parameter were clinically relevant in each treatment group and significantly superior (p < 0.001) in the lornoxicam group. Pain on movement (-45.3%), at rest (-42.0%) and at night (-42.5%) was reduced by rofecoxib, whereas improvements after treatment with lornoxicam exceeded those effects significantly (-55.8%, -55.8% and -59.9%, respectively). Shortening of the duration of morning stiffness was significantly (p < 0.001) more pronounced with lornoxicam (-66.6%) than with rofecoxib (-50.2%). Nearly three times as many patients discontinued rofecoxib treatment because of lack of efficacy compared with lornoxicam treatment (8.9% versus 3.4%). Physicians judged lornoxicam to be markedly superior to rofecoxib, since excellent efficacy was observed in 40.9% of all cases versus 20.1% with rofecoxib. Serious adverse events did not occur. Adverse events were reported in 5.4% of all lornoxicam patients compared with 12.0% of the rofecoxib recipients (p < 0.001). GI symptoms showed a slight trend of being less frequent following rofecoxib therapy. CONCLUSIONS: The results of this study confirmed the efficacy and safety of both drugs. Lornoxicam and rofecoxib are effective in the treatment of patients with activated osteoarthritis; the analgesic and anti-inflammatory effects of lornoxicam are significantly superior to those of rofecoxib without inferiority in tolerability.

DrugBank数据引用了这篇文章

药物靶点

药物	目标	类	生物	药理作用	行动
Lornoxicam	前列腺素合成酶1 G / H	蛋白质	人类	是的	抑制剂	细节
Lornoxicam	前列腺素合成酶2 G / H	蛋白质	人类	是的	抑制剂	细节