Investigation of binding process of chlorpromazine to bovine serum albumin by means of passive and active experiments.

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Rukhadze MD, Bezarashvili GS, Sidamonidze NS, Tsagareli SK

Investigation of binding process of chlorpromazine to bovine serum albumin by means of passive and active experiments.

Biomed Chromatogr. 2001 Oct;15(6):365-73.

PubMed ID

11559920 [View in PubMed

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Abstract

The association process of chlorpromazine with bovine serum albumin by both onefactoral passive and multifactoral active experiments were investigated in model systems. The dependence of absolute concentration of the free fraction of chlorpromazine on the total concentration of chlorpromazine is described by the increasing function, but the dependence of the relative concentration (free/total) on this factor is influenced by external characteristics. The concentrations of chlorpromazine, bovine serum albumin and Tritons' mixture, as principal factors of a multifactoral experiment, influence the absolute and relative values of the free fraction of chlorpromazine non-additively, ie the interaction of factors is significant.

DrugBank Data that Cites this Article

Drug Carriers

Drug	Carrier	Kind	Organism	Pharmacological Action	Actions
Acepromazine	Serum albumin	Protein	Humans	Unknown	Not Available	Details
Chlorpromazine	Serum albumin	Protein	Humans	Unknown	Not Available	Details
Pipotiazine	Serum albumin	Protein	Humans	Unknown	Not Available	Details
Thioproperazine	Serum albumin	Protein	Humans	Unknown	Not Available	Details
氨砜噻吨	Serum albumin	Protein	Humans	Unknown	Not Available	Details