Bromhexine hydrochlorideProduct ingredient forBromhexine
- Name
- Bromhexine hydrochloride
- Drug Entry
-
Bromhexine
Bromhexine is mucolytic agent used for a variety of respiratory conditions associated with increased mucus secretion. It is derived from the Adhatoda vasica plant and aids in the clearance of excess mucus, improving breathing and reducing cough. It was introduced into the market in 1963, and is widely available as an over-the-counter drug in many countries.1Recently, bromhexine and its metaboliteambroxolhave garnered interest for the potential prevention and treatment of COVID-19 due to their interactions with cell receptors in the lungs.5,6
- Accession Number
- DBSALT001092
- Structure
-
Structure for Bromhexine hydrochloride (DBSALT001092)
- Synonyms
- Bromhexine HCl
- UNII
- YC2ZOM3Z8V
- CAS Number
- 611-75-6
- Weight
-
Average: 412.59
Monoisotopic: 409.976002 - Chemical Formula
- C14H21Br2ClN2
- InChI Key
- UCDKONUHZNTQPY-UHFFFAOYSA-N
- InChI
-
InChI=1S/C14H20Br2N2.ClH/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17;/h7-8,12H,2-6,9,17H2,1H3;1H
- IUPAC Name
-
2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline hydrochloride
- SMILES
-
Cl.CN(CC1=CC(Br)=CC(Br)=C1N)C1CCCCC1
- External Links
-
- ChemSpider
- 4642584
- ChEBI
- 31303
- ChEMBL
- CHEMBL1319139
- Predicted Properties
-
Property Value Source Water Solubility 0.00362 mg/mL ALOGPS logP 4.08 ALOGPS logP 4.42 Chemaxon logS -5 ALOGPS pKa (Strongest Acidic) 19.89 Chemaxon pKa (Strongest Basic) 9.03 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 29.26 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 85.56 m3·mol-1 Chemaxon Polarizability 32.98 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon
