NAV

AER001

Identification

Generic Name
AER001
DrugBank Accession Number
DB05078
Background

AER001, an IL4/13 receptor antagonist for severe asthma and eczema currently in Phase 2 studies.

Type
Small Molecule
Groups
Investigational
Synonyms
Not Available

Ph值armacology

Indication

Investigated for use/treatment in asthma.

Reduce drug development failure rates
Build, train, & validate machine-learning models
with evidence-based and structured datasets.
See how
Build, train, & validate predictive machine-learning models with structured datasets.
See how
Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug events
Improve clinical decision support with information oncontraindications & blackbox warnings, population restrictions, harmful risks, & more.
Learn more
Avoid life-threatening adverse drug events & improve clinical decision support.
Learn more
Ph值armacodynamics

Not Available

Mechanism of action
Target Actions Organism
UInterleukin-4 receptor subunit alpha Not Available Humans
UInterleukin-13 receptor subunit alpha-2 Not Available Humans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Improve decision support & research outcomes
With structured adverse effects data, including:blackbox warnings, adverse reactions, warning & precautions, & incidence rates.
Learn more
Improve decision support & research outcomes with our structured adverse effects data.
Learn more
Toxicity

Not Available

Pathways
Not Available
Ph值armacogenomic Effects/ADRsBrowse all" title="" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug InteractionsLearn More" title="" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

药物从10个产品信息+ global regions
Our datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.
Access now
Access drug product information from over 10 global regions.
Access now
International/Other Brands
Aerovant

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
Not Available
CAS number
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

References

一般引用
Not Available
PubChem Substance
347909932

Clinical Trials

Clinical TrialsLearn More" title="" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Ph值ase Status Purpose Conditions Count
2 Completed Treatment Asthma 1
2 Completed Treatment Asthma, Allergic 1
1 Completed Treatment Asthma 1

Ph值armacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
专利
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Targets

Build, predict & validate machine-learning models
Use our structured and evidence-based datasets tounlock new
insights and accelerate drug research.
Learn more
Use our structured and evidence-based datasets to unlock new insights and accelerate drug research.
Learn more
Details 1.Interleukin-4 receptor subunit alpha
Kind
Protein
Organism
Humans
Ph值armacological action
Unknown
General Function
Receptor signaling protein activity
Specific Function
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regu...
Gene Name
IL4R
Uniprot ID
P24394
Uniprot Name
Interleukin-4 receptor subunit alpha
分子量
89657.42 Da
Details 2.Interleukin-13 receptor subunit alpha-2
Kind
Protein
Organism
Humans
Ph值armacological action
Unknown
General Function
Signal transducer activity
Specific Function
Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).
Gene Name
IL13RA2
Uniprot ID
Q14627
Uniprot Name
Interleukin-13 receptor subunit alpha-2
分子量
44176.065 Da

Drug created at October 21, 2007 22:23 / Updated at June 12, 2020 16:52