干预治疗疥疮。
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强大的M,约翰斯通P
干预治疗疥疮。
科克伦数据库系统启2007年7月18日;(3):CD000320。
- PubMed ID
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17636630 (在PubMed]
- 文摘
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背景:疥疮是一种强烈的瘙痒皮肤寄生虫感染引起的证实scabiei螨。这是一种常见的公共卫生问题,估计3亿年全球流行情况。严重副作用已经报道了一些药物用于治疗疥疮。目的:评价局部和全身药物治疗疥疮。必威国际app搜索策略:2007年2月,我们搜查了Cochrane传染病专业注册,中央(Cochrane图书馆2006年,问题1),MEDLINE、EMBASE,紫丁香,INDMED。2007年3月,我们还搜查了灰色文献和来源注册必威国际app试验。我们也检查的参考书目检索研究。选择标准:随机对照试验的药物治疗疥疮。数据收集和分析:两位作者独立评估试验质量和提取数据。结果与相对风险95%置信区间和数据结合在适当的地方。 MAIN RESULTS: Twenty small trials involving 2392 people were included. One trial was placebo controlled, 16 compared two or more drug treatments, two compared treatment regimens, and one compared different drug vehicles.Fewer treatment failures occurred by day seven with oral ivermectin in one small trial (55 participants). Topical permethrin appeared more effective than oral ivermectin (85 participants, 1 trial), topical crotamiton (194 participants, 2 trials), and topical lindane (753 participants, 5 trials). Permethrin also appeared more effective in reducing itch persistence than either crotamiton (94 participants, 1 trial) or lindane (490 participants, 2 trials). One small trial did not detect a difference between permethrin (a synthetic pyrethroid) and a natural pyrethrin-based topical treatment (40 participants). No significant difference was detected in the number of treatment failures between crotamiton and lindane (100 participants, 1 trial), lindane and sulfur (68 participants, 1 trial), benzyl benzoate and sulfur (158 participants, 1 trial), and benzyl benzoate and natural synergized pyrethrins (240 participants, 1 trial); all were topical treatments. No trials of malathion were identified. No serious adverse events were reported. A number of trials reported skin reactions in participants randomized to topical treatments. There were occasional reports of headache, abdominal pain, diarrhoea, vomiting, and hypotension. AUTHORS' CONCLUSIONS: Topical permethrin appears to be the most effective treatment for scabies. Ivermectin appears to be an effective oral treatment. More research is needed on the effectiveness of malathion, particularly when compared to permethrin, and on the management of scabies in an institutional setting and at a community level.
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- 药物