抗利尿激素代谢,催产素及其类似物(Mpa1, D-Arg8)后叶加压素(dDAVP)和[Mpa1, D-Tyr (Et) 2、Thr4, Orn8]催产素(antocin)在人类肾脏和肝匀浆。
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Fjellestad-Paulsen,必年代
抗利尿激素代谢,催产素及其类似物(Mpa1, D-Arg8)后叶加压素(dDAVP)和[Mpa1, D-Tyr (Et) 2、Thr4, Orn8]催产素(antocin)在人类肾脏和肝匀浆。
Regul Pept。1996年11月14日,67(1):新。
- PubMed ID
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8952002 (在PubMed]
- 文摘
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信息代谢的命运neurohypophyseal精氨酸抗利尿激素的荷尔蒙(avon),催产素(OT)及其类似物在人几乎是不存在的。本研究的目的是为了研究催产素的稳定性,抗利尿激素及其类似物dDAVP [Mpa1-D-Tyr2 (Et), Thr4, Orn8]催产素(antocin)在人类肾微绒毛刷状缘膜,在人类肝脏细胞膜。孵化后的肽的降解是由反相高效液相色谱法(HPLC)。AVP和OT的退化是快速的谷胱甘肽和人工肾膜微绒毛。avon,以及dDAVP、稳定与微绒毛孵化时膜没有谷胱甘肽,而不能被代谢。催产素的代谢模拟antocin也随谷胱甘肽的存在。在缺乏谷胱甘肽的亲脂性的峰值筛选了,观察更亲水峰与谷胱甘肽在高效液相色谱法。亲脂性的峰值被发现与截断coelute模拟[Mpa1, D-Tyr2 (Et), Thr4, desOrn8, Gly9]催产素。没有孵化退化肽时发生与肝细胞膜。然而,当使用原油,unpurified肝匀浆对所有肽除了antocin发生退化。 The degradation of AVP in the human unpurified liver homogenate was as rapid as in the renal microvilli membranes. Similarly, OT was more rapidly degraded in human kidney microvilli membranes in the presence of glutathione than in the human crude liver homogenate, when using equal amounts of protein in the incubations. Thus, the present investigation indicates the existence of two possible metabolic pathways, in kidney microvilli, one for OT, which did not require the presence of reduced glutathione, and one for AVP, which required the presence of reduced glutathione. Liver degradation, on the other hand, requires the hepatocytes.
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