药物动力学的福尔可定在健康志愿者单剂量和长期的研究。

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陈锆、博赫纳F索莫吉氏

药物动力学的福尔可定在健康志愿者单剂量和长期的研究。

Br中国新药杂志。1988年10月,26 (4):445 - 53。

PubMed ID

3190994 (在PubMed

]

文摘

1。福尔可定在两个单剂量的药物后,慢性政府在健康的志愿者进行了研究。2。六个科目获得单一口服剂量的20和60毫克的福尔可定根据平衡交叉设计两者之间的间隔3周的治疗。血液和唾液样本尿液收集超过168 h后每个剂量管理。随后,同一个主题收到20毫克福尔可定8小时口服10天。血液和唾液样本尿液收集在一个8 h后剂量间隔最后剂量11天。3所示。等离子体、唾液和尿液浓度的福尔可定由高效液相色谱分析测定。4所示。 After the single doses, pholcodine was absorbed rapidly (tmax = 1.6 +/- 1.2 h) and eliminated slowly with a mean half-life of 50.1 +/- 4.1 h. The renal clearance of pholcodine was 137 +/- 34 ml min-1 and was inversely correlated with urine pH (r = 0.60) but not with urine flow rate. 26.2 +/- 3.3% of the dose was excreted as unchanged pholcodine after both doses. The concentration of pholcodine in saliva was 3.6 times higher than in plasma. 5. After chronic administration, the pharmacokinetics of pholcodine were not statistically different from the single dose parameters. 6. Pholcodine did not appear to undergo conjugation. The plasma protein binding was 23.5%. Morphine, in unconjugated or conjugated form, was not detected in the urine of any subject after pholcodine administration.

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药物

福尔可定