急性和持续的影响lucinactant与poractant-alpha肺气体交换和力学与呼吸窘迫综合征过早羊羔。
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Gastiasoro-Cuesta E, Alvarez-Diaz陆地,Rey-Santano C, Arnaiz-Renedo, Loureiro-Gonzalez B, Valls-i-Soler
急性和持续的影响lucinactant与poractant-alpha肺气体交换和力学与呼吸窘迫综合征过早羊羔。
儿科。2006年2月,117 (2):295 - 303。
- PubMed ID
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16452346 (在PubMed]
- 文摘
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背景:动物,似乎protein-containing表面活性剂优于无蛋白表面活性剂。Lucinactant,包含表面活性剂的合成表面活性剂protein-B肽模拟,已被证明是有效的在动物模型和二期临床试验。迄今为止,lucinactant没有而动物表面活性剂在不成熟的动物模型。目的:目的是比较严重和持续的影响中lucinactant过早羊羔与呼吸窘迫综合征(RDS)的影响自然猪表面活性剂(poractant-alpha)。方法:5分钟后机械通气的双胞胎早产羊羔被随机分配给lucinactant组(30毫克/毫升,5.8毫升/公斤)或poractant-alpha组(80 mg / mL, 2.2毫升/公斤)。心率、系统性动脉压,动脉pH值,血气值和肺力学都记录了12个小时。结果:基线胎儿pH值是相似的两组(pH值7.27)。5分钟后机械通气,严重RDS发达(pH值:< 7.08;Paco2: > 80毫米汞柱;Pao2: < 40毫米汞柱; dynamic compliance: <0.08 mL/cm H2O per kg). After surfactant instillation, similar improvements in gas exchange and lung mechanics were observed for the lucinactant and poractant-alpha groups at 1 hour (pH: 7.3 +/- 0.1 vs 7.4 +/- 0.1; Paco2: 8 +/- 18 mm Hg vs 40 +/- 8 mm Hg; Pao2: 167 +/- 52 mm Hg vs 259 +/- 51 mm Hg; dynamic compliance: 0.3 +/- 0.1 mL/cm H2O per kg vs 0.3 +/- 0.1 mL/cm H2O per kg). The improvements in lung function were sustained, with no differences between groups. Cardiovascular profiles remained stable in both groups. CONCLUSIONS: Among preterm lambs with severe RDS, lucinactant produced improvements in gas exchange and lung mechanics similar to those observed with a porcine-derived surfactant.
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