最后修改报告的安全评估羟喹啉和硫酸羟喹啉用于化妆品。
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安徒生的一
最后修改报告的安全评估羟喹啉和硫酸羟喹啉用于化妆品。
Int J Toxicol。2006; 25增刊1:1-9。
- PubMed ID
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16835127 (在PubMed]
- 文摘
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硫酸羟喹啉是杂环酚羟喹啉是它的盐,这两个被描述为化妆品杀虫剂用于化妆品配方。在前面的化妆品成分评估(CIR)安全评估,发现可用的数据不足以支持安全。据报道,目前,一些使用美国食品和药物管理局(FDA)的行业,但行业报告CIR显示没有使用。在欧洲,羟喹啉和硫酸羟喹啉接受用作稳定剂过氧化氢冲洗干净和留在头发护理准备,与浓度的限制。羟喹啉和葡糖苷酸代谢和排泄尿液。硫酸羟喹啉和羟喹啉展览subchronic毒性和急性动物实验。100毫克剂量羟喹啉只是略微有些气恼的眼睛。羟喹啉和硫酸羟喹啉基因毒性在某些typhimirium沙门氏菌菌株的代谢活化和小鼠淋巴瘤试验。有一些证据表明增加染色体畸变的体外研究中,和姐妹染色单体交换的增加(但不是染色体畸变)与羟喹啉在小白鼠身上,但没有发现基因毒性Drosophilia伴性隐性致死试验,小鼠骨髓微核测试,一只老鼠骨髓和肝细胞微核试验,计划外在大鼠肝细胞DNA合成。羟喹啉与DNA结合在肝酶的存在。 Although the International Agency for Research on Cancer concluded that the existing evidence is inadequate to determine carcinogenicity in animals, Oxyquinoline was noncarcinogenic in several rodent feeding studies, and newly available studies using genetically altered mice, in one case carrying the human c-Ha-ras gene, demonstrated that Oxyquinoline was not carcinogenic. In clinical tests, Oxyquinoline is neither an irritant nor a sensitizer when tested at 1% in petrolatum. The available data demonstrate that Oxyquinoline and Oxyquinoline Sulfate are safe as stabilizers for hydrogen peroxide in rinse-off hair care cosmetic products in the present practices of use. For leave-on cosmetic products, however, the absence of impurities and ultraviolet (UV) absorption data resulted in a finding that the available data are insufficient to support safety. The data needed in order to complete the safety assessment of Oxyquinoline and Oxyquinoline Sulfate in leave-on cosmetic products are (1) UV absorption data -- if significant absorption occurs, then photoirritation/photosensitization data will be needed; and (2) data on impurities.
