卡瓦提取物和卡瓦吡咯酮对大鼠伏隔核神经递质水平的影响。
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鲍姆SS，希尔R, Rommelspacher H
卡瓦提取物和卡瓦吡咯酮对大鼠伏隔核神经递质水平的影响。
《神经精神药理学生物精神病学进展》1998年10月22日(7):1105-20。
- PubMed ID
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9829291 (PubMed视图］
- 摘要
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1.卡帕吡咯酮具有众所周知的精神药物特性。这种提取物最常见的作用是放松和兴奋，这取决于摄入的情况，而高剂量会导致嗜睡和骨骼肌放松。其他一些作用已被报道，如抗惊厥性质，神经保护和镇痛。目前还没有发现与神经感受器的相互作用可以解释多种行为。2.为了揭示卡帕吡咯酮对神经元功能的影响，作者利用体内微透析研究了卡帕吡咯酮对中脑边缘奖赏系统的作用。3.小剂量卡瓦提取物(20mg /kg体重i.p)引起大鼠行为和伏隔核多巴胺浓度的变化。高剂量(120 mg/kg i.p.)增加了多巴胺水平。 With respect to the individual compounds, D,L-kawain induced in low doses a decrease in dopamine levels and in higher amounts either an increase or no change in dopamine concentrations. Yangonin resulted in a decrease of dopamine levels to below the detection limit and desmethoxyyangonin in an increase of dopamine levels. Dihydrokawain, methysticin and dihydromethysticin did not produce any significant changes of dopamine levels. D,L-kawain caused a decrease in 5-HT concentrations. Some of the other kavapyrones affected 5-HT levels as well. 4. The results suggest that the relaxing and slightly euphoric actions may be caused by the activation of the mesolimbic dopaminergic neurones. Changes of the activity of 5-HT neurones could explain the sleep-inducing action.
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