猫肺片作为外围的体外制备航空公司:beta-adrenoceptor受体激动剂的比较,内分泌物和过敏性挑战肺和气管。
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Lulich公里,米切尔HW,麻雀MP
猫肺片作为外围的体外制备航空公司:beta-adrenoceptor受体激动剂的比较,内分泌物和过敏性挑战肺和气管。
Br J杂志。1976年9月,58 (1):71 - 9。doi: 10.1111 / j.1476-5381.1976.tb07694.x。
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10035年(在PubMed]
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1一个新的体外制备、孤立肺地带的猫,被描述为研究平滑肌的药物的直接影响肺的周边航空公司。准备由一条薄薄的肺实质,可以安装在一个传统的器官浴等长张力记录。其药理反应特征并与猫的孤立的气管的准备。2肺地带表现出一种内在的语气轻松的儿茶酚胺,氨茶碱和flufenamate。由组胺强烈收缩,前列腺素F2alpha,乙酰胆碱化合物48/80,去极化钾溶液和交流领域的刺激。相比之下,那只猫气管对组胺和前列腺素F2alpha并没有表现出一种内在的基调。3(-)(-)肾上腺素和异丙肾上腺素更有效的放松比气管肺地带。放松的效力顺序对异丙肾上腺素,肾上腺素和去甲肾上腺素(+ / -)在肺地带异丙肾上腺素比肾上腺素比去甲肾上腺素但在气管异丙肾上腺素比去甲肾上腺素大于或等于肾上腺素。4 beta2-Adrenoceptor选择性受体激动剂舒喘宁和特布他林更强大的比气管肺地带,暗示beta2-adrenoceptors主导肺地带。普萘洛尔是均等的抑制异丙肾上腺素relexations肺的地带和气管,而有效地抑制肺条心得宁远远低于气管,进一步支持优势beta2-adrenoceptors肺地带和beta1-adrenoceptors气管。 5 Strong Schultz-Dale type contractions were elicited in both lung strips and trachea by Ascaris lumbricoides antigen in actively sensitized cats. The initial phase of the contractile response of the lung strip following challenge was shown to be due to histamine release and was absent in the trachea. The delayed phase of the contraction which took several minutes to develop in both the mepyramine-treated lung strip and trachea was not due to prostaglandins E1, F2alpha or bradykinin, the probable mediator being slow reacting substance of anaphylaxis (SRS-A). 6 It is concluded that the isolated lung strip of the cat is useful as an in vitro model for investigating the effect of drugs on the smooth muscle of the peripheral airways of the lungs.