胃肠癌术后静脉注射大豆油与大豆油加鱼油乳剂的随机临床试验。

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姜志明，Wilmore DW，王晓荣，魏建民，张志涛，顾志智，王松，韩明敏，姜宏，于凯

胃肠癌术后静脉注射大豆油与大豆油加鱼油乳剂的随机临床试验。

中华外科杂志;2010;36(6):419 - 419。doi: 10.1002 / bjs.6999。

PubMed ID

20473991 (PubMed视图

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摘要

背景:特异性免疫营养素可以减少术后并发症的发生，缩短恢复时间。本随机试验评估了一种鱼油乳剂对胃肠癌手术后预后和免疫功能的临床疗效。方法:共有206例胃肠道或结肠癌患者随机接受单独等热量和等氮大豆油静脉输注(1.2 g / kg体重每天;对照组，分析103例)或大豆加鱼油乳剂(分别为1.0和0.2 g / kg / d;治疗组，分析100例)术后7天，每天20-24小时。结果:两组的基线数据具有可比性。感染并发症较少(第8天4例vs 12例;P = 0.066)，全身炎症反应综合征(SIRS)的发生率显著降低(4例对13例;P = 0.039)，住院时间显著缩短(平均(s.d.) 15(5)天比17(8)天;P = 0.041)。 Total postoperative medical costs were comparable in the two groups (mean(s.d.) US $ 1269(254) and 1302(324) in treatment and control groups respectively; P = 0.424). The median (interquartile range) difference in CD4/CD8 between days 1 and 8 after surgery was + 0.30 (0.06 to 0.79) in patients receiving fish oil and + 0.20 (-0.19 to 0.55) in controls (P = 0.021). No severe adverse events occurred in either group. CONCLUSION: Fish oil emulsion-supplemented parenteral nutrition significantly reduced SIRS and length of hospital stay. These clinical benefits may be related to normalization of cellular immune functions and modulation of the inflammatory response.

引用本文的药物库数据

药物

大豆油