甲状腺激素及其影响:一个新的视角。
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赫伯特AJ
甲状腺激素及其影响:一个新的视角。
杂志牧师综眼费罗斯Soc。2000年11月,75 (4):519 - 631。doi: 10.1017 / s146479310000556x。
- PubMed ID
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11117200 (在PubMed]
- 文摘
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甲状腺激素非常疏水和那些表现出生物活性是3 ',5 ',3,5-L-tetraiodothyronine (T4)、3’, 5, 3-L-triiodothyronine (T3), 3 ', 5 ', 3-L-triiodothyronine (rT3)和3、5 ',-L-diiothyronine (3 5-T2)。在生理pH值、离解的酚醛-哦组iodothyronines是一个重要的决定因素的物理化学生物效应的影响。当非电离这些iodothyronines强烈两亲的。是建议iodothyronines生物膜在脊椎动物的正常成分。等离子体的成人脊椎动物,游离T4、T3监管picomolar范围内同时蛋白结合的T4、T3维护摩尔。thyroid-hormone-binding血浆蛋白的功能是确保一个更distrubtion整个身体。各种iodothyronines是由三种类型的膜结合在脊椎动物细胞deiodinase酶系统。deiodinases的分布变化之间的组织和每个人都有一个独特的发展概况。甲状腺激素。(1)核受体模式尤为重要的甲状腺激素轴控制等离子体和细胞水平的激素。 (2) These hormones are strongly associated with membranes in tissues and normally rigidify these membranes. (3) They also affect the acyl composition of membrane bilayers and it is suggested that this is due to the cells responding to thyroid-hormone-induced membrane rigidificataion. Both their immediate effects on the physical state of membranes and the consequent changes in membrane composition result in several other thyroid hormone effects. Effects on metabolism may be due primarily to membrane acyl changes. There are other actions of thyroid hormones involving membrane receptors and influences on cellular interactions with the extracellulara matrix. The effects of thyroid hormones are reviewed and appear to b combinations of these various modes of action. During development, vertebrates show a surge in T4 and other thyroid hormones, as well as distinctive profiles in the appearance of the deiodinase enzymes and nuclear receptors. Evidence from the use of analogues supports multiple modes of action. Re-examination of data from th early 1960s supports a membrane action. Findings from receptor 'knockout' mice supports an important role for receptors in the development of the thyroid axis. These iodothyronines may be better thought of as 'vitamone'-like molecules than traditional hormonal messengers.
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