血浆铜蓝蛋白:铜运输蛋白氧化酶活动至关重要。
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弗里登E,谢长廷海关
血浆铜蓝蛋白:铜运输蛋白氧化酶活动至关重要。
副词Enzymol遗传代数领域杂志。1976;44:187 - 236。doi: 10.1002/9780470122891.的互动。
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775938年(在PubMed]
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血浆铜蓝蛋白,蓝copper-protein脊椎动物的血浆,综述了主要从功能的角度来看。但是我们已经调查了国家化学和分子中铜的影响的最近的数据Ryden(13日28)。他的观察表明,除非是采取特别的措施隔离的血浆铜蓝蛋白降解,可能蛋白水解,产生了各种大小的碎片。当孤立时,这些碎片似乎是由共价相互作用。比较他们的催化和光谱特性揭示了从单一均匀无显著差异134000种分子量Ryden孤立的方法。另一方面,均匀分子可能不同的属性对构象和三维参数高度敏感。三种类型的铜原子在血浆铜蓝蛋白已确定,但是他们的氨基酸环境仍然是未知的。血浆铜蓝蛋白具有重要的氧化酶活性铁(II)和大量的芳香胺和苯酚。其铁氧化酶活性,发现了它是铜和铁代谢分子之间的联系。血浆铜蓝蛋白动员铁进入血浆从铁储存在肝脏细胞。 An equally important duty is that ceruloplasmin, after its rapid biosynthesis in the liver, serves as a major copper transport vehicle, comparable to transferrin. Evidence is accumulating that the copper atoms of ceruloplasmin are a prerequisite for copper utilization in the biosynthesis of cytochrome oxidase and other copper proteins. The ability of ceruloplasmin to release copper at specific cellular sites may be related to its broad substrate spectrum of biological reducing agents. A possible third role of ceruloplasmin is as a contributor to the regulation of the balance of biogenic amines through its oxidase action on the epinephrine and the hydroxyindole series. Thus ceruloplasmin is a copper-protein with several important functions, all of which are directly related to its oxidase activity.