头孢呋辛axetil。综述了其抗菌活性、药代动力学特性及治疗效果。

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Perry CM, Brogden RN

头孢呋辛axetil。综述了其抗菌活性、药代动力学特性及治疗效果。

《药物》1996年7月;52(1):125-58。

PubMed ID

8799689 (PubMed视图

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摘要

头孢呋辛酯是一种口服头孢菌素，可迅速水解为活性母体化合物头孢呋辛。头孢呋辛具有广泛的体外抗菌活性，包括对甲氧西林敏感的葡萄球菌和常见的呼吸道病原体肺炎链球菌、流感嗜血杆菌、卡他莫拉菌(布氏菌)和a组乙型溶血性链球菌。头孢呋辛对乙型内酰胺酶阳性呼吸道病原体流感嗜血杆菌和卡他罗分枝杆菌具有广谱活性;它对肺炎链球菌的青霉素敏感株和-中间株也有活性。在临床试验中，头孢呋辛酯(每日两次)已被评估用于治疗上呼吸道和下呼吸道感染，并已证明与现有的抗菌药物(包括阿莫西林/克拉维酸和头孢克洛)具有类似的疗效。最近研究表明，在急性中耳炎或急性支气管炎患者中，头孢呋辛酯治疗5天与头孢呋辛酯或阿莫西林/克拉维酸治疗10天一样有效。头孢呋辛酯治疗A组乙型溶血性链球菌扁桃体炎的疗效至少与苯氧甲基青霉素(青霉素V)相同。多项研究评估了头孢呋辛酯作为静脉-口服序贯治疗住院下呼吸道感染患者的口服成分的疗效。在每项研究中，患者接受头孢呋辛静脉注射约2天，随后服用头孢呋辛酯5 - 10天。在比较研究中，头孢呋辛序贯疗法与阿莫西林/克拉维酸序贯疗法和全疗程静脉注射头孢呋辛、头孢替安或头孢哌酮一样有效。 Adults with urinary tract infections and skin infections were also effectively treated with cefuroxime axetil, as were adults and adolescents with early stage lyme disease. Cefuroxime axetil is associated with a low incidence of adverse events, with gastrointestinal disturbances being the most frequently observed. Thus, cefuroxime axetil is an effective and convenient treatment for a wide range of infections and may be considered a therapeutic option when empirical treatment of community-acquired infections is required. Moreover, given the promising results of several intravenous/oral sequential treatment studies, cefuroxime axetil may also become established as an oral component of sequential treatment regimens.

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头孢呋辛