胃动素受体激动剂红霉素刺激通过胆碱能通路饥饿和食物摄入量。
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Deloose E·沃斯·R,詹森P, Van den马瑞医生啊,范Oudenhove L, Depoortere我策略J
胃动素受体激动剂红霉素刺激通过胆碱能通路饥饿和食物摄入量。
是中国减轻。2016年3月,103 (3):730 - 7。doi: 10.3945 / ajcn.115.113456。Epub 2016年1月27日。
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26817505 (在PubMed]
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背景:Motilin-induced第三阶段的收缩已经被认定为一个饥饿的信号。这些三期收缩发生迁移运动复杂(MMC)的一部分,禁食期间胃肠道的收缩性模式。主观之间的机制参与本协会饥饿的感觉和胃肠蠕动在MMC在很大程度上是未知的,但是,其刺激食物摄取的能力。目的:我们试图调查饥饿的发生高峰和他们的关系第三阶段的收缩,2)评估这种关系是否cholinergically驱动,和3)评估胃动素受体激动剂的能力红霉素诱导食物摄入量。设计:开发一个算法来检测饥饿的山峰。协会与第三阶段的收缩,研究了14个健康志愿者(男性50%;意思是+ / - SEM年龄:25 + / - 2 y;意思是+ / - SEM身体质量指数(BMI;公斤/米(2)):23 + / - 1]。药物诱导的影响,第三阶段的收缩在饥饿的发生高峰和胆碱能通路进行评估的参与在14名健康志愿者(男性43%; age: 29 +/- 3 y; BMI: 23 +/- 1). Last, the effect of erythromycin administration on food intake was examined in 15 healthy volunteers (40% men; age: 28 +/- 3 y; BMI: 22 +/- 1). RESULTS: The occurrence of hunger peaks and their significant association with phase III contractions was confirmed (P < 0.0001). Pharmacologically induced phase III contractions were also significantly associated with hunger peaks (P < 0.05), and this association involved a cholinergic pathway. Administering erythromycin significantly stimulated food intake compared with placebo (53% +/- 13% compared with 10% +/- 5%; P < 0.05). CONCLUSIONS: Motilin-induced phase III contractions induced hunger feelings through a cholinergic pathway. Moreover, erythromycin stimulated food intake, suggesting a physiologic role of motilin as an orexigenic signal from the gastrointestinal tract. This trial was registered at www.clinicaltrials.gov as NCT02633579.