氯雷他定:每日一次或服用不具有镇静作用的抗组胺剂的剂量。

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Barenholtz哈,麦克劳德

氯雷他定:每日一次或服用不具有镇静作用的抗组胺剂的剂量。

DICP。1989年6月,23 (6):445 - 50。

PubMed ID

2525847 (在PubMed

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文摘

氯雷他定是一个添加到类的nonsedating抗组胺药包括terfenadine、阿司咪唑、acrivastine。氯雷他定是化学与三环类抗抑郁药有关。动物数据表明,氯雷他定进入大脑的斤斤计较,它有一个三倍更大的亲和力周边与中央组胺1-receptors相比。氯雷他定有一个主要代谢物,descarbethoxyloratadine,四倍比父母更加活跃的药物。氯雷他定在1 - 2小时到达血浆浓度峰值;代谢物在3 - 4个小时。各自的消除半衰期大约10到20个小时。开始行动和持续时间1小时内至少24小时。建议每天换一次剂量。一般来说,氯雷他定是一样有效的现有抗组胺药缓解过敏性鼻炎的症状,荨麻疹,抑制水疱形成。 Reports of sedation and other adverse reactions are no more frequent than found with placebo. Tachyphylaxis has not been noted in humans, and there is minimal potential for drug interactions based on animal data. Loratadine and terfenadine have comparable therapeutic applications. Both have shown minimal adverse effects, but loratadine has a quicker onset and longer duration of action. These two agents are useful for acute allergic reactions. In contrast, astemizole has an onset of action of several days and is most useful for prophylactic treatment of seasonal allergies.

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药物

氯雷他定