常见的基因多态性影响人类营养需求胆碱。
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da Costa KA, Kozyreva噩、歌曲J Galanko是的,费舍尔LM,蔡塞尔SH
常见的基因多态性影响人类营养需求胆碱。
FASEB j . 2006年7月,20 (9):1336 - 44。
- PubMed ID
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16816108 (在PubMed]
- 文摘
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人类吃的饮食缺乏的必需营养素胆碱可以开发器官功能障碍。我们假设常见的单核苷酸多态性(snp)在胆碱代谢基因影响这种营养的饮食要求。57人被喂以低胆碱饮食,直到他们开发了器官功能障碍或42天。我们检测DNA单核苷酸多态性的等位基因与磁化率发展与胆碱缺乏相关器官功能障碍。我们发现一个SNP在启动子区域的磷脂酰乙醇胺N-methyltransferase基因(PEMT;-744 G - - > C;rs12325817) 18 23 C等位基因携带者的发达器官功能障碍(78%)低胆碱饮食(优势比25,P = 0.002)。第一个两个snp胆碱脱氢酶基因的编码区(CHDH;+ 318 C - - >;rs9001)对胆碱缺乏保护作用,而第二个CHDH变体(+ 432 G - - > T; rs12676) was associated with increased susceptibility to choline deficiency. A SNP in the PEMT coding region (+5465 G-->A; rs7946) and a betaine:homocysteine methyltransferase (BHMT) SNP (+742 G-->A; rs3733890) were not associated with susceptibility to choline deficiency. Identification of common polymorphisms that affect dietary requirements for choline could enable us to identify individuals for whom we need to assure adequate dietary choline intake.