酮康唑2%的多中心随机试验和锌羟基吡啶硫酮1%严重头皮屑洗发水和脂溢性皮炎。

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Pierard-Franchimont C,戈氏V, Decroix J, Pierard通用电气

酮康唑2%的多中心随机试验和锌羟基吡啶硫酮1%严重头皮屑洗发水和脂溢性皮炎。

皮肤:皮肤杂志杂志》2002;11 - 12月15 (6):434 - 41。

PubMed ID

12476017 (在PubMed

]

文摘

酮康唑(刃)和锌羟基吡啶硫酮(ZPT)化合物活性与细胞种虫害酵母,据信发挥重要作用在头皮屑和脂溢性皮炎。我们比较的有效性和安全性刃2%,ZPT 1%缓解严重的头皮屑的洗发水配方和脂溢性皮炎。这个开放的随机、平行对照试验中开始两周试车阶段期间,受试者应用中性non-antidandruff洗发水。紧随其后的是一个四周随机治疗阶段和随后的四周后续阶段不治疗。洗头治疗期间每周进行两次尿酮体组,每周至少两次的ZPT组按照标签说明。共有343名受试者招募进入审判。的331个合格的志愿者,171被随机分配到刃2%和160 ZPT 1%。进行临床评估。有利影响证明了两种洗发露,但是效果明显更好的偈语2%,实现了73%的改善头皮屑严重程度得分为67% ZPT星期4 1% (p < 0.02)。疾病的复发率也显著降低后刃比ZPT 1%治疗后治疗2%。 As a consequence, the overall clearing of the skin condition at the end of treatment and follow-up phase was in favor of the KET 2% formulation (p = 0.004). Side effects were minimal. It is concluded that after a 4-week treatment, KET 2% shampoo was significantly superior to ZPT 1% shampoo in the treatment of subjects with severe dandruff or seborrheic dermatitis of the scalp. It is our assumption that this difference is noticeable for the patient and as a consequence relevant. Both formulations were well tolerated.

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酮康唑