重复口服剂量宽容与ciclosporin治疗的狗和oclacitinib三个星期。
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Panteri, Strehlau G, Helbig R,普罗斯特C,多赛特K
重复口服剂量宽容与ciclosporin治疗的狗和oclacitinib三个星期。
兽医杂志。2016;2月27 (1):22-e7。doi: 10.1111 / vde.12278。Epub 2015年12月11日。
- PubMed ID
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26660461 (在PubMed]
- 文摘
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背景:Ciclosporin和oclacitinib免疫调制剂批准用于治疗犬过敏性皮肤炎。管理短疗程的初强的松ciclosporin疗法加速这种药物的功效;oclacitinib有强的松的快速止痒的效果类似。目的:评价口服oclacitinib公差和ciclosporin同时给出三个星期。动物:两组八米格鲁猎犬。方法:狗被随机分配接受oclacitinib独自(0.4 - -0.6毫克/公斤每天两次14天之后七天每天一次)或结合ciclosporin(5毫克/公斤每天一次)三个星期。他们每天检查,不良事件记录。收集血液样本在驯化阶段,每周在治疗和研究结束的血液学、临床化学和凝固的评估。结果:治疗后没有异常的临床观察oclacitinib单独或与ciclosporin,除了腹泻接收这两种药物在两只狗。三只狗从每组经历了短暂的食欲不振; three dogs treated with oclacitinib had mild weight loss. Clinical pathology parameters remained within the reference range for beagle dogs at that facility. CONCLUSIONS AND CLINICAL IMPORTANCE: The concomitant administration of ciclosporin and oclacitinib for three weeks to beagles was well tolerated and was not associated with an increase in the number of adverse events or laboratory abnormalities beyond those associated with oclacitinib given alone.
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