营养的重要性果糖和糖醇。
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王YM,范眼睛J
营养的重要性果糖和糖醇。
为减轻。1981;1:437 - 75。
- PubMed ID
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6821187 (在PubMed]
- 文摘
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人体新陈代谢的果糖、山梨醇、D-mannitol和木糖醇都有记录。在人类中,山梨糖醇,木糖醇单剂量口服20 g或少和果糖在70 g或最有可能可以完全吸收。这些糖可以维护,独立或近独立完整性或碳水化合物的细胞和动物的生长要求。D-mannitol的吸收是不超过80%,更多的泻药。一般来说,没有不利影响非渗透性腹泻后口服糖。瞬态高尿酸血被认为在某些人类。慢性毒性的终身使用这些糖在人类和其他灵长类动物是未知的。然而,两年图尔库糖有研究表明果糖和木糖醇的安全。两年在小鼠和大鼠喂养实验表明可能的高木糖醇饮食致癌性。异常的细胞增长也记录在动物喂食高百分比的山梨醇和蔗糖。 Long-term mannitol feeding experiments also revealed an increased incidence of benign thymic tumors in rats. Intravenous feeding of fructose, xylitol, and sorbitol causes major concern. The toxicity is total-dose and infusion-rate dependent. The physical toxicity induced by hyperosmolar effect of the concentrated infusion solutions can be lethal. The primary metabolic toxicities, mainly lactic acidosis and hypruricemia, are reversible. The suggested safe infusion rate of these sugars is 0.25 g/kg/h; sporadic toxic observations have been reported at this or lower doses (0.125 g/kg/h). The combination of glucose, fructose, xylitol, and sorbitol mixture intravenously is in use in Europe due to the critical threshold of each element. There are positive findings from the use of the combination in human illness (114). The beneficial effect of xylitol, mannitol, sorbitol, and fructose in decreasing order has been well documented in the prevention of dental caries in animals and in humans. Oral organisms do not appear to metabolically adapt to xylitol even after 4 years of in vivo exposure. This was based on the quantitation of xylitol dehydrogenase activity in saliva and oral organisms. In addition, a therapeutic and preventive effect for xylitol in human and animal dental caries has been demonstrated. There appears to be at least a theoretical edge in the dietary use of fructose, xylitol, and sorbitol in diabetics.(ABSTRACT TRUNCATED AT 400 WORDS)